MedtechInsight.com

TABLE OF CONTENTS

EXECUTIVE SUMMARY

i. Drug and Fluid Injection/Infusion Systems

ii. Transdermal Patch-Based Drug Delivery Systems

iii. Inhaled Drug Therapy Systems

1. ESTABLISHED METHODS OF DRUG DELIVERY

1.1 Oral Administration

1.2 Transdermal Delivery

1.3 Transmucosal Administration

1.4 Pulmonary Administration

1.5 Injection and Infusion

1.5.1 Needle Injection

1.5.2 Jet Injection

1.5.3 Intravascular Infusion

1.5.4 Intraspinal Infusion

1.5.5 Intra-Operative Site Infusion

1.5.6 Intraperitoneal/Transperitoneal Infusion

2. DRUG AND FLUID DELIVERY BY INJECTION/INFUSION METHODS

2.1 Drug Injection/Infusion Devices

2.2 Major Drug Injection/Infusion Applications

2.2.1 Anesthesia Delivery

2.2.2 Antibiotic/Antiviral Therapy

2.2.3 Bone Marrow and Organ Transplant Support Therapy

2.2.3.1 Bone Marrow Transplantation

2.2.3.2 Organ Transplantation

2.2.4 Cardiovascular Disease Infusion Therapy

2.2.4.1 Anticoagulation and Thrombolysis

2.2.4.2 Treatment of Congestive Heart Failure

2.2.5 Chemotherapy

2.2.6 Diabetes Management

2.2.7 Hydration Therapy

2.2.8 Nutritional Support

2.2.8.1 Total Parenteral Nutrition

2.2.8.2 Enteral Nutrition

2.2.9 Pain Management/Patient-Controlled Analgesia

2.2.10 Transfusion/Replacement Therapy

2.2.11 Other Infusion-Based Drug Therapies

2.2.11.1 Biotechnology Therapies

2.2.11.1.1 Cytokine Therapy

2.2.11.1.2 Growth Hormone Therapy

2.2.11.1.3 Interferon Therapy

2.2.11.2 Infertility Therapy

2.2.11.3 Management of High-Risk Pregnancies

2.2.11.4 Perinatal Therapy

2.3 Injection/Infusion Therapy Technologies and Markets

2.3.1 Syringe Technology and Product Markets

2.3.1.1 Standard Multipurpose Syringes

2.3.1.2 Safety Syringes

2.3.1.3 Insulin Syringes

2.3.1.4 Market Forecast

2.3.1.5 Competitive Analysis

2.3.2 Insulin Pen Technology and Product Market

2.3.2.1 Market Forecast

2.3.2.2 Competitive Analysis

2.3.3 Needleless Jet Injector Technology and Product Market

2.3.3.1 Market Forecast

2.3.3.2 Competitive Analysis

2.3.4 Infusion Pump Technology and Product Markets

2.3.4.1 Volumetric Pumps

2.3.4.1.1 Market Forecast

2.3.4.1.2 Competitive Analysis

2.3.4.2 Syringe Pumps

2.3.4.2.1 Market Forecast

2.3.4.2.2 Competitive Analysis

2.3.4.3 Ambulatory Pumps

2.3.4.3.1 Market Forecast

2.3.4.3.2 Competitive Analysis

2.3.4.4 Disposable Pumps

2.3.4.4.1 Market Forecast

2.3.4.4.2 Competitive Analysis

2.3.4.5 Implantable Pumps

2.3.4.5.1 Market Forecast

2.3.4.5.2 Competitive Analysis

2.3.4.6 External Insulin Pumps

2.3.4.6.1 Market Forecast

2.3.4.6.2 Competitive Analysis

2.3.4.7 Enteral Pumps and Gravity Systems

2.3.4.7.1 Market Forecast

2.3.4.7.2 Competitive Analysis

2.3.4.8 Intravascular Gravity Infusion Systems

2.3.4.8.1 Market Forecast

2.3.4.8.2 Competitive Analysis

2.3.5 Vascular Access Technologies and Product Markets

2.3.5.1 Short Peripheral Catheters

2.3.5.1.1 Market Forecast

2.3.5.1.2 Competitive Analysis

2.3.5.2 Midline Catheters

2.3.5.2.1 Market Forecast

2.3.5.2.2 Competitive Analysis

2.3.5.3 Peripherally Inserted Central Catheters

2.3.5.3.1 Market Forecast

2.3.5.3.2 Competitive Analysis

2.3.5.4 Central Venous Catheters

2.3.5.4.1 Market Forecast

2.3.5.4.2 Competitive Analysis

2.3.5.5 Implantable Ports

2.3.5.5.1 Market Forecast

2.3.5.5.2 Competitive Analysis

3. TRANSDERMAL DRUG DELIVERY

3.1 Transdermal Patch Technology

3.1.1 Transdermal Active Transport Systems

3.2 Transdermal Patch Applications and Product Markets

3.2.1 The Management of Angina Pectoris and Hypertension

3.2.1.1 Nitroglycerin and Clonidine Patch Products

3.2.1.2 Market Forecast

3.2.1.3 Competitive Analysis

3.2.2 Estrogen Replacement Therapy

3.2.2.1 Estrogen Patch Products

3.2.2.2 Market Forecast

3.2.2.3 Competitive Analysis

3.2.3 Smoking Cessation

3.2.3.1 Nicotine Replacement Therapy Products

3.2.3.1.1 Nicotine Patch

3.2.3.1.2 Nicotine Gum

3.2.3.1.3 Nicotine Inhaler

3.2.3.1.4 Nicotine Nasal Spray

3.2.3.1.5 BUPROPION

3.2.3.2 Market Forecast

3.2.3.3 Competitive Analysis

3.2.4 Pain Management Therapy

3.2.4.1 Cancer Pain

3.2.4.2 Postherpetic Neuralgia

3.2.4.3 Analgesic Patch Products

3.2.4.3.1 Duragesic Fentanyl Patch

3.2.4.3.2 Lidoderm Lidocaine Patch

3.2.4.4 Market Forecast

3.2.4.5 Competitive Analysis

4. INHALATION DRUG THERAPY

4.1 Chronic Obstructive Respiratory Disorders Targeted by

Inhalation Therapy

4.1.1 Bronchial Asthma

4.1.2 Chronic Bronchitis

4.1.3 Emphysema

4.1.4 Cystic Fibrosis

4.2 Inhalation Drug Therapy for Chronic Obstructive

Respiratory Disorders

4.2.1 Bronchodilators

4.2.2 Anti-Inflammatory Agents

4.3 Inhalation Drug Therapy Delivery Technology

4.3.1 Metered-Dose Inhalers

4.3.1.1 Breath-Actuated Metered-Dose Inhalers

4.3.1.2 Chlorofluorocarbon-Free Metered-Dose Inhalers

4.3.1.3 Spacer Devices

4.3.2 Dry-Powder Inhalers

4.3.3 Nebulizers

4.3.4 Metered-Dose and Dry-Powder Inhalers for the

Treatment of Chronic Obstructive Respiratory Disorders

4.3.5 Emerging Nonrespiratory Applications of Inhalation

Drug Therapy

4.3.5.1 Inhaled Insulin Technologies

4.4 Major Inhaled Drug Therapy Systems, Market Analysis

4.4.1 Market Forecast for Chronic Obstructive Respiratory

Disorder Devices

4.4.2 Market Forecast for Inhaled Insulin Products

4.4.3 Competitive Analysis

5. COMPANY PROFILES

5.1 Abbott Laboratories

5.2 Alaris Medical Systems, Inc.

5.3 Arrow International, Inc.

5.4 Aventis Pharma/Aventis Group

5.5 C.R. Bard, Inc.

5.6 Baxter Healthcare Corporation/Baxter International

5.7 Becton Dickinson and Company

5.8 Bioject Medical Technologies, Inc.

5.9 Boehringer Ingelheim Pharmaceuticals, Inc.

/Boehringer Ingelheim Group

5.10 Disetronic Medical Systems, Inc./Disetronic Group

/Disetronic Holding AG

5.11 Endo Pharmaceuticals, Inc.

5.12 Johnson & Johnson

5.13 GlaxoSmithKline

5.14 Horizon Medical Products, Inc.

5.15 I-Flow Corporation

5.16 Kendall Healthcare Products Corporation/Tyco

International LTD

5.17 Medex/Saint-Gobain Performance Plastics/Saint-Gobain Group

5.18 Medtronic, Inc.

5.19 MiniMed, Inc.

5.20 Novartis Pharmaceuticals Corporation/Novartis AG

5.21 Novo Nordisk Pharmaceuticals, Inc./Novo Nordisk AS

5.22 Schering-Plough Corporation

5.23 SIMS Deltec, Inc./Smith Industries Medical Systems/Smiths Group PLC

COMPANY LISTING

LIST OF EXHIBITS

Exhibit ES-1: Drug Delivery Products, by Type, Market Forecast, 2000-2005

Exhibit ES-2: Injection/Infusion Drug and Fluid Delivery Systems, Market Forecast, 2000-2005

Exhibit ES-3: Transdermal Patch Products, Market Forecast, 2000-2005

Exhibit ES-4: Dry-Powder and Metered-Dose Inhalers for the Treatment of Chronic Obstructive Respiratory Disorders, and Insulin Delivery Systems, Market Forecast, 2000-2005

Exhibit 1-1: Advantages and Disadvantages of Common Drug Delivery Modalities

Exhibit 2-1: Injection/Infusion Drug and Fluid Delivery Systems, Market Forecast, 2000-2005

Exhibit 2-2: 2001, Selected Safety Syringes

Exhibit 2-3: 2001, Selected Insulin Syringes

Exhibit 2-4: Syringes, Market Forecast, 2000-2005

Exhibit 2-5: 2000, Syringes Market, Share by Supplier

Exhibit 2-6: 2001, Selected Insulin Pens

Exhibit 2-7: Insulin Pen Products, Market Forecast, 2000-2005

Exhibit 2-8: 2000, Insulin Pen Products Market, Share by Supplier

Exhibit 2-9: 2001, Selected Jet Injector Products

Exhibit 2-10: Jet Injector Products, Market Forecast, 2000-2005

Exhibit 2-11: 2000, Jet Injector Products Market, Share by Supplier

Exhibit 2-12: Infusion Pump Products, Market Forecast, 2000-2005

Exhibit 2-13: 2001, Selected Volumetric Pumps

Exhibit 2-14: Volumetric Pump Products, Market Forecast, 2000-2005

Exhibit 2-15: 2000, Volumetric Pump Products Market, Share by Supplier

Exhibit 2-16: 2001, Selected Syringe Pumps

Exhibit 2-17: Syringe Pump Products, Market Forecast, 2000-2005

Exhibit 2-18: 2000, Syringe Pumps Market, Share by Supplier

Exhibit 2-19: 2001, Selected Ambulatory Pumps

Exhibit 2-20: Ambulatory Pump Products, Market Forecast, 2000-2005

Exhibit 2-21: 2000, Ambulatory Pumps Market, Share by Supplier

Exhibit 2-22: 2001, Selected Disposable Infusion Pumps

Exhibit 2-23: Disposable Infusion Pumps, Market Forecast, 2000-2005

Exhibit 2-24: 2000, Disposable Infusion Pumps Market, Share by Supplier

Exhibit 2-25: 2001, Selected Implantable Infusion Pumps

Exhibit 2-26: Implantable Infusion Pumps, Market Forecast, 2000-2005

Exhibit 2-27: 2000, Implantable Infusion Pumps Market, Share by Supplier

Exhibit 2-28: 2001, Selected External Insulin Pumps

Exhibit 2-29: External Insulin Pump Products, Market Forecast, 2000-2005

Exhibit 2-30: 2000, External Insulin Pump Products Market, Share by Supplier

Exhibit 2-31: 2001, Selected Enteral Nutrition Pumps

Exhibit 2-32: Enteral Nutrition Pumps and Disposable Products, Market Forecast, 2000-2005

Exhibit 2-33: 2000, Enteral Nutrition Pumps and Disposable Products Market, Share by Supplier

Exhibit 2-34: Intravenous Gravity Infusion Systems, Market Forecast, 2000-2005

Exhibit 2-35: 2000, Intravenous Gravity Infusion Systems Market, Share by Supplier

Exhibit 2-36: 2001, Selected Vascular Catheters and Implantable Ports

Exhibit 2-37: Vascular Catheters and Implantable Ports, Market Forecast, 2000-2005

Exhibit 2-38: Short Peripheral Catheters, Market Forecast, 2000-2005

Exhibit 2-39: 2000, Short Peripheral Catheters Market, Share by Supplier

Exhibit 2-40: Midline Catheters, Market Forecast, 2000-2005

Exhibit 2-41: 2000, Midline Catheters Market, Share by Supplier

Exhibit 2-42: Peripherally Inserted Central Catheters, Market Forecast, 2000-2005

Exhibit 2-43: 2000, Peripherally Inserted Central Catheters Market, Share by Supplier

Exhibit 2-44: Central Venous Catheters, Market Forecast, 2000-2005

Exhibit 2-45: 2000, Central Venous Catheters Market, Share by Supplier

Exhibit 2-46: Implantable Ports, Market Forecast, 2000-2005

Exhibit 2-47: 2000, Implantable Ports Market, Share by Supplier

Exhibit 3-1: Transdermal Patch Products, Market Forecast, 2000-2005

Exhibit 3-2: 2001, Selected Nitroglycerin and Clonidine Transdermal Patch Products

Exhibit 3-3: Nitroglycerin and Clonidine Patch Products, Market Forecast, 2000-2005

Exhibit 3-4: 2000, Nitroglycerin Patch Products Market, Share by Supplier

Exhibit 3-5: 2001, Selected Estrogen Patch Products

Exhibit 3-6: Estrogen Replacement Therapy Products, Market Forecast, 2000-2005

Exhibit 3-7: 2000, Estrogen Patch Products Market, Share by Supplier

Exhibit 3-8: 2001, Selected Nicotine Patch Products

Exhibit 3-9: Nicotine Replacement Therapy Patch and Gum Products, Market Forecast, 2000-2005

Exhibit 3-10: 2000, Nicotine Replacement Therapy Patch Products Market, Share by Supplier

Exhibit 3-11: 2001, Selected Analgesic Patch Products

Exhibit 3-12: Analgesic Patch Products, Market Forecast, 2000-2005

Exhibit 3-13: 2000, Analgesic Patch Products Market, Share by Supplier

Exhibit 4-1: Prevalence of Chronic Obstructive Respiratory Disorders, 2000 and 2005

Exhibit 4-2: 2001, Selected Inhalation Therapy Agents for the Treatment of Chronic Obstructive Respiratory Disorders

Exhibit 4-3: 2001, Comparative Analysis of Inhalation Drug-Delivery Systems

Exhibit 4-4: 2001, Selected Dry-Powder Inhaler- and Metered-Dose Inhaler-Based Drugs for Chronic Obstructive Respiratory Disorder Indications

Exhibit 4-5: Dry-Powder and Metered-Dose Inhalers for the Treatment of Chronic Obstructive Respiratory Disorders, and Insulin Delivery Systems, Market Forecast, 2000-2005

Exhibit 4-6: Dry-Powder and Metered-Dose Inhalers for the Treatment of Chronic Obstructive Respiratory Disorders, Market Forecast, by Drug Type, 2000-2005

Exhibit 4-7: Inhaled Insulin Products, Market Forecast, 2002-2005

Exhibit 4-8: 2000, Dry-Powder and Metered-Dose Inhalers for the Treatment of Chronic Obstructive Respiratory Disorders, Share by Supplier