In an effort to address the major barriers to the adoption of minimally invasive techniques in wound closure, manufacturers and researchers alike are racing to develop sutureless methods for wound closure.  As a result, a variety of endoscopic suturing devices, energy-based technologies, and glues and sealants have appeared on the market in recent years.  As the appropriate regulatory bodies worldwide approve more innovative products, dramatic changes may be seen in the segmentation of the wound closure products market.

Together, the wound closure devices markets in Europe and the U.S. are valued at approximately $3.4 billion.  Of this, surgical sutures account for an estimated 50% of sales, staplers and staples for 29%, surgical sealants and glues for 9.5%, and wound closure strips for 3%.  Over the next five years, burgeoning sales of surgical sealants and glues, automated suturing products, and energy-based closure devices are expected to drive the value of the combined European and U.S. wound closure devices market to nearly $3.9 billion. 

This dynamic report from Medtech Insight includes analyses of products, technologies, current and forecast markets, competitors, and opportunities in the European and U.S. wound closure technologies market.  Covered topics include autologous-processed, collagen- and albumin-based, cyanoacrylate-based, fibrin, and polymer-based surgical sealants and glues; automated suturing devices; energy-based closure devices; surgical staplers; surgical sutures; and wound closure strips.

TABLE OF CONTENTS

EXECUTIVE SUMMARY

i.   Skin and the Fundamentals of Wound Closure

ii.   Wound Closure Devices Markets

a. Surgical Sutures

b. Surgical Staples

c. Wound Closure Strips

d. Surgical Sealants and Glues

e. Energy-Based Closure Devices

f.   Automated Suturing Devices

1. PHYSIOLOGY OF WOUND CLOSURE

1.1 Layers of the Skin and Supporting Structures

1.1.1 Epidermis

1.1.2 Dermis

1.1.3 Subcutaneous Tissue

1.1.4 Fascia

1.1.5 Muscle

1.1.6 Bone

1.2 Phases of Wound Closure

1.2.1 Hemostatic Phase

1.2.2 Inflammatory Phase

1.2.3 Proliferative Phase

1.2.4 Remodeling Phase

1.3 Factors Affecting Wound Closure

1.3.1 Intrinsic Factors

1.3.1.1 Age and Health Status

1.3.1.2 Body Build

1.3.1.3 Nutritional Status

1.3.2 Extrinsic Factors

1.3.2.1 Desiccation

1.3.2.2 Hydration

1.3.2.3 Infection

1.3.2.4 Maceration

1.3.2.5 Medications

1.3.2.6 Necrotic Tissue and Debris

1.3.2.7 Oxygen

1.3.2.8 Stress

1.3.2.9 Temperature

1.3.2.10 Wound Creation and Depth

1.3.2.11 Wound Closure Techniques

1.3.2.12 Other Extrinsic Factors

1.3.3 Complications of Wound Closure

1.3.3.1 Scarring

1.3.3.2 Bleeding

1.4 Wound Classification

1.4.1 Amputations

1.4.2 Burns

1.4.3 Surgical Wounds

1.4.4 Traumatic Wounds/Lacerations

1.4.5 Ulcers

1.4.5.1 Arterial Ulcers

1.4.5.2 Diabetic Ulcers

1.4.5.3 Pressure Ulcers

1.4.5.4 Venous Ulcers

1.5 Incidence of Major Wounds

2. TRADITIONAL WOUND CLOSURE PRODUCTS

2.1 Surgical Sutures

2.1.1 Suture Classifications

2.1.1.1 Monofilament and Multifilament Sutures

2.1.1.2 Nonabsorbable and Absorbable Sutures

2.1.1.2.1 Nonabsorbable Sutures

2.1.1.2.2 Absorbable Sutures

2.1.2 Market Forecasts

2.1.3 Competitive Analyses

2.2 Surgical Staplers

2.2.1 Types of Staples and Staplers

2.2.2 Surgical Staples and Staplers in the United States

2.2.3 Surgical Staples and Staplers in Europe 

2.2.4 Market Forecasts

2.2.5 Competitive Analyses

2.3 Wound Closure Strips

2.3.1 Market Forecasts

2.3.2 Competitive Analyses

3. EMERGING WOUND CLOSURE PRODUCTS

3.1 Surgical Sealants and Glues

3.1.1 Applications of Surgical Sealants and Glues

3.1.1.1 Cardiac and Vascular Surgeries

3.1.1.2 General Surgery

3.1.1.3 Thoracic Surgery

3.1.1.4 Plastic and Ear, Nose, and Throat Surgeries

3.1.1.5 Neurosurgery/Spine Surgery

3.1.2 Fibrin Sealants

3.1.2.1 Composition

3.1.2.2 Application Methods

3.1.2.3 Competitors and Their Products

3.1.2.3.1 Aventis Behring

3.1.2.3.2 Baxter BioScience/Baxter International

3.1.2.3.3 CryoLife

3.1.2.3.4 Haemacure Corporation 

3.1.2.3.5 OMRIX biopharmaceuticals

3.1.2.3.6 PPL Therapeutics

3.1.3 Autologous-Processed Sealants

3.1.3.1 Competitors and Their Products

3.1.3.1.1 Harvest Technologies

3.1.3.1.2 Interpore Cross International

3.1.3.1.3 PlasmaSeal/Hanuman Medical

3.1.3.1.4 ThermoGenesis Corporation

3.1.4 Collagen- and Albumin-Based Sealants

3.1.4.1 Competitors and Their Products

3.1.4.1.1 Cohesion Technologies/Angiotech
 Pharmaceuticals

3.1.4.1.2 CryoLife

3.1.4.1.3 Fusion Medical Technologies/Baxter
 International

3.1.4.1.4 Surgical Sealants, Inc.

3.1.4.1.5 Tissuemed

3.1.5 Cyanoacrylate-Based Sealants

3.1.5.1 Competitors and Their Products

3.1.5.1.1 Aesculap/B.Braun Melsungen

3.1.5.1.2 BTG International

3.1.5.1.3 Closure Medical

3.1.5.1.4 GEM

3.1.5.1.5 GluStitch

3.1.5.1.6 Henkel Loctite

3.1.5.1.7 MedLogic Global/Advanced Medical Solutions

3.1.6 Polymer-and Resorcinol/Aldehyde-Based Sealants

3.1.6.1 Competitors and Their Products

3.1.6.1.1 Berlin Heart

3.1.6.1.2 Cohesion Technologies/Angiotech
 Pharmaceuticals

3.1.6.1.3 Confluent Surgical

3.1.6.1.4 Genzyme Biosurgery/Genzyme

3.1.6.1.5 Medafor

3.1.7 Market Forecast

3.1.8 Competitive Analysis

3.2 Energy-Based Closures

3.2.1 Radiofrequency

3.2.1.1 Monopolar versus Bipolar

3.2.1.2 Competitors and Their Products

3.2.1.2.1 Gyrus Medical

3.2.1.2.2 TissueLink Medical

3.2.1.2.3 Valleylab/Tyco International

3.2.2 Ultrasonic Closure and Suturing

3.2.2.1 Competitors and Their Products

3.2.2.1.1 Axya Medical

3.2.2.1.2 Bonutti Technologies

3.2.2.1.3 Ethicon Endo-Surgery/Johnson & Johnson

3.2.2.1.4 Olympus America/Olympus Optical Company

3.2.2.1.5 Therus Corporation

3.2.3 Thermal Wound Closure

3.2.4 Market Forecast

3.2.5 Competitive Analysis

3.3 Automated Suturing Devices

3.3.1 Competitors and Their Products

3.3.1.1 C.R. Bard

3.3.1.2 Ethicon Endo-Surgery/Johnson & Johnson

3.3.1.3 LSI Solutions

3.3.1.4 NDO Surgical

3.3.1.5 ONUX Medical

3.3.1.6 PARÉ Surgical

3.3.1.7 Smith & Nephew

3.3.1.8 SuturTek

3.3.1.9 United States Surgical/Johnson & Johnson

3.3.2 Market Forecast

3.3.3 Competitive Analysis

4. COMPANY PROFILES

4.1     3M Company

4.2     Axya Medical, Inc.

4.3     Baxter International, Inc.

4.4     BTG International, Inc.

4.5     Closure Medical Corporation

4.6     Cohesion Technologies, Inc./Angiotech Pharmaceuticals, Inc.

4.7     CryoLife, Inc.

4.8     Genzyme Biosurgery, Inc./Genzyme Corporation

4.9     Haemacure Corporation 

4.10    Henkel Loctite Corporation/Henkel Group

4.11    Interpore Cross International, Inc.

4.12    Johnson & Johnson

4.13    PPL Therapeutics PLC

4.14    Smith & Nephew PLC

4.15    ThermoGenesis Corporation

4.16    Tyco Healthcare/Tyco International LTD

APPENDIX:  COMPANY LISTING

LIST OF EXHIBITS

Exhibit ES-1:    United States, Surgical Sutures, Market Forecast, 2002-2007

Exhibit ES-2:    Europe, Surgical Sutures, Market Forecast, 2002-2007

Exhibit ES-3:    United States, Surgical Staplers, Market Forecast, 2002-2007

Exhibit ES-4:    Europe, Surgical Staplers, Market Forecast, 2002-2007

Exhibit ES-5:    United States, Wound Closure Strips, Market Forecast, 2002-2007

Exhibit ES-6:    Europe, Wound Closure Strips, Market Forecast, 2002-2007

Exhibit ES-7:    United States, Surgical Sealants and Glues, Market Forecast, 2002-2007

Exhibit ES-8:    Europe, Surgical Sealants and Glues, Market Forecast, 2002-2007

Exhibit ES-9:    United States, Energy-Based Wound Closure Devices, Market Forecast, 2002-2007

Exhibit ES-10:   United States, Automated Suturing Devices, Market Forecast, 2002-2007

Exhibit 1-1:      Skin Layers and Supporting Structures

Exhibit 1-2:      Phases Involved in the Wound Closure Process

Exhibit 1-3:      Intrinsic and Extrinsic Factors Affecting Wound Closure

Exhibit 1-4:      Classification of Wounds, by Etiology

Exhibit 1-5:      Classification of Wounds, by Morphology

Exhibit 1-6:      Classification of Wounds, by Severity

Exhibit 1-7:      2002, United States, Inpatient and Outpatient Surgical Procedures

Exhibit 1-8:      2002, United States, Wound Incidence

Exhibit 1-9:      2002, Europe, Wound Incidence

Exhibit 2-1:      2003, United States, Selected Surgical Sutures

Exhibit 2-2:      2003, Europe, Selected Surgical Sutures

Exhibit 2-3:      United States, Surgical Sutures, Market Forecast, 2002-2007

Exhibit 2-4:      Europe, Surgical Sutures, Market Forecast, 2002-2007

Exhibit 2-5:      2002, United States, Surgical Sutures Market, Share by Supplier

Exhibit 2-6:      2002, Europe, Surgical Sutures Market, Share by Supplier

Exhibit 2-7:      2003, United States, Selected Surgical Staplers

Exhibit 2-8:      2003, Europe, Selected Surgical Staplers

Exhibit 2-9:      United States, Surgical Staplers, Market Forecast, 2002-2007

Exhibit 2-10:     Europe, Surgical Staplers, Market Forecast, 2002-2007

Exhibit 2-11:     2002, United States, Surgical Staplers Market, Share by Supplier

Exhibit 2-12:     2002, Europe, Surgical Staplers Market, Share by Supplier

Exhibit 2-13:     2003, Unites States, Selected Wound Closure Strips

Exhibit 2-14:     2003, Europe, Selected Wound Closure Strips

Exhibit 2-15:     United States, Wound Closure Strips, Market Forecast, 2002-2007

Exhibit 2-16:     Europe, Wound Closure Strips, Market Forecast, 2002-2007

Exhibit 2-17:     2002, United States, Wound Closure Strips Market, Share by Supplier

Exhibit 2-18:     2002, Europe, Wound Closure Strips Market, Share by Supplier

Exhibit 3-1:      Fibrin Sealants and Cyanoacrylates, Comparison of Properties

Exhibit 3-2:      Usage of Surgical Sealants and Glues, by Specialty

Exhibit 3-3:      Usage of Surgical Sealants and Glues in Cardiac and Vascular Surgeries

Exhibit 3-4:      Usage of Surgical Sealants and Glues in General Surgery

Exhibit 3-5:      Usage of Surgical Sealants and Glues in Thoracic Surgery

Exhibit 3-6:      Representation of Fusion Medical Technologies/Baxter International’s FloSeal’s Sealant Abilities

Exhibit 3-7:      2003, Selected Cyanoacrylate Surgical Sealants

Exhibit 3-8:      Representation of Medafor’s TraumaDEX Sealant Abilities

Exhibit 3-9:      2003, Europe, Selected Surgical Sealants and Glues

Exhibit 3-10:     Acquisition, Distribution, and Merger Activity, Surgical Sealants and Glues Manufacturers

Exhibit 3-11:     Surgical Sealants and Glues, Regulatory Status

Exhibit 3-12:     United States, Surgical Sealants and Glues, Market Forecast, 2002-2007

Exhibit 3-13:     Europe, Surgical Sealants and Glues, Market Forecast, 2002-2007

Exhibit 3-14:     2002, United States, Surgical Sealants and Glues Market, Share by Supplier

Exhibit 3-15:     2002, Europe, Surgical Sealants and Glues Market, Share by Supplier

Exhibit 3-16:     Effects of Temperature on Collagenous Tissue

Exhibit 3-17:     LigaSure Product Line, Valleylab/Tyco International

Exhibit 3-18:     Components of AxyaWeld Technology, Axya Medical

Exhibit 3-19:     United States, Energy-Based Wound Closure Devices, Market Forecast, 2002-2007

Exhibit 3-20:     2002, United States, Energy-Based Wound Closure Devices Market, Share by Supplier

Exhibit 3-21:     EndoCinch Procedure, C.R. Bard

Exhibit 3-22:     Endoscopic Plicator System, NDO Surgical

Exhibit 3-23:     FastClose Device, SuturTek

Exhibit 3-24:     United States, Automated Suturing Devices, Market Forecast, 2002-2007

Exhibit 3-25:     2002, United States, Automated Suturing Devices Market, Share by Supplier

Copyright 2003, Medtech Insight, LLC