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U.S. Markets for Skin Replacements and Substitutes and Active Wound Repair Modulators
Report #A140
- February 2013
121 Pages – 22 Exhibits – 9 Company Profiles

In 2011, U.S. sales of tissue-engineered skin replacements/substitutes and active wound repair modulators totaled approximately $404.8 million; of this, skin replacements/substitutes (including traditional products that are used for a broad range of indications including cosmetic and reconstructive surgery, as well as future introductions of tissue-engineered skin replacement/substitute products for a variety of wound healing applications) accounted for an estimated 78.1% of sales, and active wound repair modulators (consisting only of growth factors, the only FDA approved product in this market to date) accounted for the remaining 21.9% of sales. Over the forecast period covered by this report, combined sales are expected to increase at a compound annual rate of 6.3%, reaching an estimated $549.7 million in the year 2016.

This new report from Medtech Insight includes analyses of products, technologies, current and forecast markets, competitors, and opportunities in the U.S. skin replacements/substitutes and active wound repair modulators market. Topics discussed in this report include an overview of clinical issues in wound management, tissue-engineered skin replacements/substitutes (e.g., epidermal equivalents, dermal equivalents, and multilayer equivalents), active wound repair modulators (e.g., growth factors, gene therapy agents, stem cells, antibiotics/anti-infectives, hormones, matrix metalloproteinase inhibitors, and neuropeptides), analyses of market forecasts and market shares, and profiles of leading competitors and products in these markets.

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U.S. Markets for Skin Replacements and Substitutes and Active Wound Repair Modulators


February 2013


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Reports are produced exclusively by Medtech Insight, through extensive primary and secondary research among the clinicians, researchers, and competitors in the marketplace, and draw upon the industry expertise of a network of industry insiders. Medtech Insight exhaustively corroborates the data as a baseline for completing forward-looking analysis and providing insight into product, technology and market evolution.





i.       Tissue-Engineered Skin Replacements/Substitutes

ii.       Active Wound Repair Modulators

a.      Growth Factors

b.      Gene Therapy

c.      Stem Cells

iii.      Combined Market Forecast


Exhibit ES-1:    Tissue-Engineered Skin Replacements and Substitutes, Market Forecast, 2011-2016

Exhibit ES-2:    Growth Factors, Market Forecast, 2011-2016

Exhibit ES-3:    Tissue-Engineered Skin Replacements/Substitutes and Active Wound Repair Modulators, Combined Market Forecast, 2011-2016



1.1 Physiology of Wound Closure

1.1.1 Layers of the Skin and Supporting Structures Epidermis Dermis Hypodermis Fascia Muscle Bone

1.1.2 Wound Closure Process Hemostasis Inflammation Proliferation Remodeling Phase

1.2 Factors Affecting Wound Closure

1.2.1 Intrinsic Factors Age and Chronic Illness Body Composition Nutritional Status

1.2.2 Extrinsic Factors Ambient Temperature Desiccation/Hydration Infection Maceration Medication and Other Treatment Modalities Necrotic Tissue and Debris Oxygen Stress Wound Creation and Depth Wound Closure Techniques Other Extrinsic Factors

1.2.3 Complications of Wound Healing Scarring Bleeding

1.3 Wound Types

1.3.1 Illness-Related Wounds Etiology Arterial Ulcers Diabetic Ulcers Venous Ulcers Epidemiology

1.3.2 Pressure Ulcers Etiology Epidemiology

1.3.3 Surgical Wounds Etiology Epidemiology

1.3.4 Traumatic Wounds Etiology Abrasions, Contusions, and Lacerations Amputations Burns Epidemiology


Exhibit 1-1:      The Skin’s Layers and Supporting Structures

Exhibit 1-2:      Phases of the Wound Closure Process

Exhibit 1-3:      Intrinsic and Extrinsic Factors Affecting Wound Closure

Exhibit 1-4:      Illness-Related Wounds, Facts and Figures, 1996-2006, and 2009

Exhibit 1-5:      Pressure Ulcers, Facts and Figures, 1996-2006, and 2009

Exhibit 1-6:      Stages of Pressure Ulcers

Exhibit 1-7:      Surgical Wounds, Facts and Figures, 1996-2006, and 2009

Exhibit 1-8:      Lacerations and Other Types of Traumatic Wounds, Facts and Figures, 1996-2006, and 2009

Exhibit 1-9:      Amputations, Facts and Figures, 1996-2006, and 2009

Exhibit 1-10:    Burns, Facts and Figures, 1996-2006, and 2009

Exhibit 1-11:    Classification of Burns, by Mechanism of Injury

Exhibit 1-12:    Classification of Burns, by Extent of Injury



2.1 Allografts

2.2 Autografts

2.3 Xenografts

2.4 Autologous and Tissue-Engineered Skin Replacements/Substitutes

2.4.1 Epidermal Equivalent Products

2.4.2 Dermal Equivalent Products

2.4.3 Multilayer Equivalent Products

2.5 Market Forecast

2.6 Competitive Analysis


Exhibit 2-1:      2013, Selected Current and Emerging Tissue-Engineered Skin Replacements and Substitutes

Exhibit 2-2:      Tissue-Engineered Skin Replacements and Substitutes, Market Forecast, 2011-2016

Exhibit 2-3:      2011, Tissue-Engineered Skin Replacements and Substitutes Market, Share by Supplier



3.1 Growth Factors

3.1.1 Growth Factor Classification Fibroblast Growth Factors Transforming Growth Factors Epidermal Growth Factors Platelet-Derived Growth Factors Insulin-Like Growth Factors Keratinocyte Growth Factors Vascular Endothelial Growth Factors Autologous Growth Factors Arteriocyte Medical Systems Biomet Cytomedix Harvest Technologies/Terumo Summary of Angiogenic Growth Factors

3.1.2 Competitors and Products

3.1.3 Market Forecast

3.2 Gene Therapy Agents

3.3 Stem Cells

3.3.1 Types of Stem Cells Embryonic Stem Cells Adult Stem Cells Cord Blood Stem Cells

3.3.2 The Role of Stem Cells in Wound Healing

3.3.3 Market Status

3.4 Other Active Wound Repair Modulators and Pharmaceuticals

3.4.1 Antibiotics and Anti-Infectives

3.4.2 Hormones

3.4.3 Matrix Metalloproteinase Enzyme Inhibitors

3.4.4 Neuropeptides in Diabetic Wounds

3.4.5 Other Products


Exhibit 3-1:      Selected Growth Factors in Development for Wound Healing Applications

Exhibit 3-2:      The Angiogenesis Process

Exhibit 3-3:      2012, Selected Angiogenic Growth Factors

Exhibit 3-4:      Growth Factors, Market Forecast, 2011-2016



4.1       Biomet, Inc.

4.2       Forticell Bioscience, Inc.

4.3       Genentech, Inc./F. Hoffmann-La Roche LTD

4.4       Genzyme Corporation/Sanofi SA

4.5       Integra LifeSciences, Inc./ Integra LifeSciences Holdings Corporation

4.6       LifeCell Corporation/Kinetic Concepts, Inc.

4.7       Organogenesis, Inc.

4.8       Smith & Nephew PLC

4.9       TEI Biosciences, Inc.




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