Peripheral atherosclerosis, the most common form of peripheral vascular disease, affects approximately 8 million to 12 million people in the U.S. annually. 

In 2004, approximately 3.2 million diagnostic and therapeutic interventional peripheral vascular disease procedures were performed in the U.S., generating $841.4 million in corresponding product sales.  Growth in these procedures is expected to occur at a compound annual rate of 5.3% during the forecast period covered by this report, reaching a total of 4.1 million by the year 2009, with corresponding product sales growing at a higher compound annual rate of 9.7%, generating approximately $1.3 billion in product sales.  Established and emerging devices used in therapeutic peripheral vascular disease procedures will account for approximately 93.6% of total interventional peripheral vascular product sales in the year 2009, or $1.2 billion.  

This dynamic report from Medtech Insight includes analyses of products and technologies, current and forecast markets, competitors, and opportunities in the U.S. market for peripheral vascular disease products. 

Covered topics in this report include intravascular ultrasound systems; laser and mechanical atherectomy systems; mechanical thrombectomy systems; peripheral endovascular embolization products; peripheral vascular angiography and angioplasty devices such as balloon catheters, guiding catheters, guidewires, sheaths, and related accessories; vascular puncture closure systems; vena cava filters; and novel and emerging peripheral interventional products including those for chronic total occlusion crossing, endovascular cryotherapy, and therapeutic angiogenesis.

TABLE OF CONTENTS AND LIST OF EXHIBITS

EXECUTIVE SUMMARY

i.   Overview of Peripheral Vascular Disease

a.  Peripheral Atherosclerosis

b.  Aortic Aneurysm

c.  Deep-Vein Thrombosis and Pulmonary Embolism

d.  Chronic Venous Insufficiency

ii.   Peripheral Interventional Radiology Procedure Volumes and Product Markets

a.  Diagnostic Peripheral Interventional Radiology Technologies

i.   Peripheral Angiography Devices

ii.   Intravascular Ultrasound Systems

b.  Established Therapeutic Peripheral Interventional Radiology Technologies

i.   Peripheral Percutaneous Transluminal Angioplasty Devices

ii.   Mechanical Atherectomy Systems

iii.  Catheter-Directed Thrombolysis Systems

iv.  Mechanical Thrombectomy Products

v.  Peripheral Endovascular Embolization Products

vi.  Vena Cava Filters

vii. Vascular Puncture Closure Products

c.  Emerging Peripheral Interventional Radiology Technologies

i.   Cryoplasty Devices

ii.   Chronic Total Occlusion Crossing Systems

iii.  Therapeutic Angiogenesis Products

iii.  Report Methodology

Exhibit ES-1:    Diagnostic and Therapeutic Peripheral Vascular Disease-Related Interventions, Procedure Volumes Forecast, 2004-2009

Exhibit ES-2:    Interventional Peripheral Vascular Diagnostic and Therapeutic Products, Market Forecast, 2004-2009

Exhibit ES-3:    Interventional Peripheral Vascular Diagnostic Products, Market Forecast, 2004-2009

Exhibit ES-4:    Peripheral Angiography Products, Market Forecast, 2004-2009

Exhibit ES-5:    Intravascular Ultrasound Catheters, Market Forecast, 2004-2009

Exhibit ES-6:    Established Interventional Peripheral Vascular Therapeutic Products, Market Forecast, 2004-2009

Exhibit ES-7:    Peripheral Angioplasty Products, Market Forecast, 2004-2009

Exhibit ES-8:    Peripheral Mechanical Atherectomy, Market Forecast, 2004-2009

Exhibit ES-9:    Peripheral Catheter-Directed Thrombolysis Products, Market Forecast, 2004-2009

Exhibit ES-10:   Peripheral Mechanical Thrombectomy Systems, Market Forecast, 2004-2009

Exhibit ES-11:   Peripheral Endovascular Embolization Products, Market Forecast, 2004-2009

Exhibit ES-12:   Vena Cava Filter Systems, Market Forecast, 2004-2009

Exhibit ES-13:   Peripheral Intervention-Related Vascular Puncture Closure Systems, Market Forecast, 2004-2009

Exhibit ES-14:   Peripheral Interventions Involving Novel and Emerging Techniques, Procedure Volumes Forecast, 2004-2009

Exhibit ES-15:   Novel and Emerging Peripheral Interventional Therapy Products, Market Forecast, 2004-2009

Exhibit ES-16:   Peripheral Cryoplasty Products, Market Forecast, 2004-2009

Exhibit ES-17:   Powered Peripheral Chronic Total Occlusions Crossing Products, Market Forecast, 2004-2009

Exhibit ES-18:   Peripheral Therapeutic Angiogenesis Products, Market Forecast, 2004-2009

Exhibit ES-19:   2004, Peripheral Interventional Systems Market, Share by Supplier

1. OVERVIEW OF PERIPHERAL VASCULAR DISEASE

1.1 Anatomy and Physiology of the Circulatory System

1.2 Peripheral Vascular Disease

1.2.1 Peripheral Atherosclerosis

1.2.1.1 Etiology

1.2.1.2 Epidemiology

1.2.2 Aortic Aneurysm

1.2.2.1 Etiology

1.2.2.2 Epidemiology

1.2.3 Deep-Vein Thrombosis and Pulmonary Embolism

1.2.3.1 Etiology

1.2.3.2 Epidemiology

1.2.4 Chronic Venous Insufficiency

1.2.4.1 Etiology

1.2.4.2 Epidemiology

Exhibit 1-1:    2006, Peripheral Atherosclerosis in the United States, Facts and Figures

Exhibit 1-2:    2006, Aortic Aneurysm in the United States, Facts and Figures

Exhibit 1-3:    2006, Deep-Vein Thrombosis in the United States, Facts and Figures

Exhibit 1-4:    Classification of Chronic Venous Insufficiency

Exhibit 1-5:    2006, Chronic Venous Insufficiency in the United States, Facts and Figures

2. CLINICAL MANAGEMENT OF PERIPHERAL VASCULAR DISEASE

2.1 Diagnosis of Peripheral Vascular Disease

2.1.1 Noninvasive Diagnosis

2.1.1.1 Ankle/Brachial Index

2.1.1.2 Exercise Tolerance Testing

2.1.1.3 Photoplethysmography and Air Plethysmography

2.1.1.4 Ultrasound Imaging

2.1.1.4.1 Doppler Ultrasound

2.1.1.4.2 Duplex Ultrasound

2.1.1.4.3 Three-Dimensional Ultrasound

2.1.1.4.4 Contrast-Enhanced Ultrasound

2.1.1.5 Computed Tomography

2.1.1.5.1 Spiral Computed Tomography

2.1.1.5.2 Electron Beam Computed Tomography

2.1.1.5.3 Multislice Computed Tomography

2.1.1.5.4 Computed Tomography Angiography

2.1.1.6 Magnetic Resonance Imaging

2.1.1.6.1 Magnetic Resonance Angiography

2.1.1.6.1.1 Time-of-Flight Magnetic Resonance Angiography

2.1.1.6.1.2 Phase-Contrast Magnetic Resonance Angiography

2.1.1.6.1.3 Contrast-Enhanced Magnetic Resonance Angiography

2.1.1.6.1.4 High-Definition Magnetic Resonance Angiography

2.1.1.7 Thermography

2.1.1.8 Monoclonal Antibody-Based Imaging

2.1.2 Interventional Peripheral Vascular Disease Diagnosis

2.1.2.1 Peripheral Angiography

2.1.2.1.1 Peripheral Arterial Angiography

2.1.2.1.1.1 Lower Extremity Vessels

2.1.2.1.1.2 Pulmonary Embolism

2.1.2.1.1.3 Acute Mesenteric Ischemia

2.1.2.1.1.4 Chronic Mesenteric Ischemia

2.1.2.1.1.5 Acute Gastrointestinal Bleeding

2.1.2.1.1.6 Abdominal Malignancy

2.1.2.1.2 Peripheral Venous Angiography

2.1.2.1.2.1 Deep-Vein Thrombosis

2.1.2.1.2.2 Visceral Venography

2.1.2.1.2.3 Portal Venography

2.1.2.1.3 Procedure Volumes Forecast

2.1.2.2 Intravascular Ultrasound

2.1.2.2.1 Description

2.1.2.2.2 Procedure Volumes Forecast

2.2 Treatment of Peripheral Vascular Disease

2.2.1 Lifestyle Management

2.2.1.1 Exercise Therapy

2.2.1.2 Cigarette Smoking Cessation

2.2.1.3 Compression Therapy

2.2.1.4 Diabetes and Hypertension Management

2.2.2 Drug Therapy

2.2.2.1 Lipid-Lowering Drugs

2.2.2.2 Antiplatelet Therapy

2.2.3 Surgery

2.2.3.1 Peripheral Artery Surgery

2.2.3.1.1 Femoropopliteal Bypass

2.2.3.1.2 Thromboendarterectomy

2.2.3.2 Chronic Venous Insufficiency Surgery

2.2.3.2.1 Skin Grafting

2.2.3.2.2 Sclerotherapy

2.2.3.2.3 Superficial Vein Stripping

2.2.3.2.4 Open Subfascial Perforating Vein Interruption

2.2.3.2.5 Subfascial Endoscopic Perforating Vein Surgery

2.2.3.2.6 Deep-Vein Reconstruction

2.2.4 Interventional Peripheral Vascular Disease Treatment Procedures

2.2.4.1 Percutaneous Transluminal Angioplasty

2.2.4.1.1 Description

2.2.4.1.2 Procedure Volumes Forecast

2.2.4.2 Endovascular Abdominal Aortic Aneurysm Repair

2.2.4.2.1 Description

2.2.4.2.2 Procedure Volumes Forecast

2.2.4.3 Mechanical Atherectomy

2.2.4.3.1 Description

2.2.4.3.2 Procedure Volumes Forecast

2.2.4.4 Catheter-Directed Thrombolysis

2.2.4.4.1 Description

2.2.4.4.2 Procedure Volumes Forecast

2.2.4.5 Mechanical Thrombectomy

2.2.4.5.1 Description

2.2.4.5.2 Procedure Volumes Forecast

2.2.4.6 Endovascular Embolization

2.2.4.6.1 Description

2.2.4.6.2 Uterine Artery Embolization in Fibroid Management

2.2.4.6.3 Procedure Volumes Forecast

2.2.4.7 Vena Cava Filter Placement

2.2.4.7.1 Description

2.2.4.7.2 Procedure Volumes Forecast

2.2.4.8 Vascular Puncture Closure

2.2.4.8.1 Description

2.2.4.8.2 Procedure Volumes Forecast

Exhibit 2-1:    Diagnostic and Therapeutic Peripheral Vascular Disease-Related Interventions, Procedure Volumes Forecast, 2004-2009

Exhibit 2-2:    Peripheral Angiography, Procedure Volumes Forecast, 2004-2009

Exhibit 2-3:    Intravascular Ultrasound, Procedure Volumes Forecast, 2004-2009

Exhibit 2-4:    Peripheral Angioplasty and Stenting, Procedure Volumes Forecast, 2004-2009

Exhibit 2-5:    Endovascular Abdominal Aortic Aneurysm Repair, Procedure Volumes Forecast, 2004-2009

Exhibit 2-6:    Peripheral Mechanical Atherectomy, Procedure Volumes Forecast, 2004-2009

Exhibit 2-7:    Peripheral Catheter-Directed Thrombolysis, Procedure Volumes Forecast, 2004-2009

Exhibit 2-8:    Peripheral Mechanical Thrombectomy, Procedure Volumes Forecast, 2004-2009

Exhibit 2-9:    Peripheral Endovascular Embolization, Procedure Volumes Forecast, 2004-2009

Exhibit 2-10:  Vena Cava Filter Placement, Procedure Volumes Forecast, 2004-2009

Exhibit 2-11:  Vascular Puncture Closure Associated with Peripheral Vascular Disease-Related Interventions, Procedure Volumes Forecast, 2004-2009

3. EMERGING PERIPHERAL REVASCULARIZATION TECHNOLOGIES

3.1 Endovascular Cryotherapy

3.1.1 Description

3.1.2 Procedure Volumes Forecast

3.2 Chronic Total Occlusion Traversing Techniques

3.2.1 Transcatheter Systems

3.2.1.1 Mechanical CTO Crossing Systems

3.2.1.2 Laser CTO Crossing Systems

3.2.1.3 Procedure Volumes Forecast

3.2.1.4 Alternative Systems under Development

3.2.1.4.1 Radiofrequency Ablation

3.2.1.4.2 High-Frequency Mechanical Vibrations

3.2.1.4.3 Endovascular Sonotherapy

3.2.1.4.4 Subintimal Angioplasty

3.3 Therapeutic Angiogenesis

3.3.1 Growth Factor/Gene-Based Treatments

3.3.1.1 Emerging Therapies

3.3.1.1.1 Catheter-Based Administration of Vascular Endothelial Growth Factor-2 Transgene

3.3.1.1.2 EW-A-401 Gene Transfer Compound

3.3.1.1.3 Genetically Engineered Plasmid Deoxyribonucleic Acid Coding

3.3.1.1.4 Transgene Coding for Developmental Endothelial Locus-1 Protein

3.3.2 Stem Cell Therapies

3.3.2.1 Clinical Experience

3.3.2.1.1 Tissue Repair Cells

3.3.2.1.2 Granulocyte Colony-Stimulating Factor/ Peripheral Blood Mononuclear Cells

3.3.2.1.3 Autologous Bone Marrow-Derived Progenitor Cells

3.3.2.1.4 Autologous Peripheral Blood Endothelial Progenitor Cells

3.3.3 Procedure Volumes Forecast

Exhibit 3-1:    Peripheral Cryoplasty, Procedure Volumes Forecast, 2004-2009

Exhibit 3-2:    Laser and Mechanical Chronic Total Occlusion Crossings, Procedure Volumes Forecast, 2004-2009

Exhibit 3-3:    Advantages and Disadvantages of Growth Factor-Based and Cellular Angiogenic Therapies

Exhibit 3-4:    Peripheral Angiogenic Therapy, Procedure Volumes Forecast, 2004-2009

4. PERIPHERAL INTERVENTIONAL RADIOLOGY PRODUCTS MARKET

4.1 Diagnostic Peripheral Interventional Products

4.1.1 Angiography

4.1.1.1 Products/Technologies

4.1.1.1.1 Catheters

4.1.1.1.2 Guidewires

4.1.1.1.3 Sheaths

4.1.1.1.4 Accessories

4.1.1.1.5 Venography Devices

4.1.1.2 Market Forecast

4.1.1.3 Competitive Analysis

4.1.2 Intravascular Ultrasound

4.1.2.1 Products/Technologies

4.1.2.2 Market Forecast

4.1.2.3 Competitive Analysis

4.2 Therapeutic Peripheral Interventional Products

4.2.1 Angioplasty

4.2.1.1 Products/Technologies

4.2.1.1.1 Balloon Catheters

4.2.1.1.2 Guiding Catheters

4.2.1.1.3 Guidewires

4.2.1.1.4 Introducers/Sheaths

4.2.1.1.5 Accessories

4.2.1.2 Market Forecast

4.2.1.3 Competitive Analysis

4.2.2 Mechanical Atherectomy

4.2.2.1 Products/Technologies

4.2.2.2 Market Forecast

4.2.2.3 Competitive Analysis

4.2.3 Catheter-Directed Thrombolysis

4.2.3.1 Products/Technologies

4.2.3.2 Market Forecast

4.2.3.3 Competitive Analysis

4.2.4 Mechanical Thrombectomy

4.2.4.1 Products/Technologies

4.2.4.2 Market Forecast

4.2.4.3 Competitive Analysis

4.2.5 Peripheral Endovascular Embolization

4.2.5.1 Products/Technologies

4.2.5.2 Market Forecast

4.2.5.3 Competitive Analysis

4.2.6 Vena Cava Filter Placement

4.2.6.2 Market Forecast

4.2.6.3 Competitive Analysis

4.2.7 Vascular Puncture Closure

4.2.7.1 Products/Technologies

4.2.7.2 Market Forecast

4.2.7.3 Competitive Analysis

4.3 Emerging Peripheral Interventional Treatments

4.3.1 Cryoplasty

4.3.1.1 Products/Technologies

4.3.1.2 Market Forecast

4.3.2 Chronic Total Occlusion Traversing

4.3.2.1 Mechanical Chronic Total Occlusion Crossing Systems

4.3.2.2 Laser Chronic Total Occlusion Crossing Systems

4.3.2.3 Market Forecast

4.3.2.4 Competitive Analysis

4.3.3 Therapeutic Angiogenesis

4.3.3.1 Products/Technologies

4.3.3.2 Market Forecast

Exhibit 4-1:    Interventional Peripheral Vascular Diagnostic and Therapeutic Products, Market Forecast, 2004-2009

Exhibit 4-2:    Interventional Peripheral Vascular Diagnostic Products, Market Forecast, 2004-2009

Exhibit 4-3:    2006, Selected Peripheral Angiography Catheters

Exhibit 4-4:    Peripheral Angiography Products, Market Forecast, 2004-2009

Exhibit 4-5:    2004, Peripheral Angiography Products Market, Share by Supplier

Exhibit 4-6:    2006, Selected Peripheral Intravascular Ultrasound Catheters

Exhibit 4-7:    Intravascular Ultrasound Catheters, Market Forecast, 2004-2009

Exhibit 4-8:    2004, Intravascular Ultrasound Catheters Market, Share by Supplier

Exhibit 4-9:    Established Interventional Peripheral Vascular Therapeutic Products, Market Forecast, 2004-2009

Exhibit 4-10:  2006, Selected Peripheral Angioplasty Catheters

Exhibit 4-11:  Peripheral Angioplasty Products, Market Forecast, 2004-2009

Exhibit 4-12:  2004, Peripheral Transluminal Angioplasty Products Market, Share by Supplier

Exhibit 4-13:  2006, Selected Peripheral Mechanical Atherectomy Systems

Exhibit 4-14:  Peripheral Mechanical Atherectomy, Market Forecast, 2004-2009

Exhibit 4-15:  2004, Peripheral Mechanical Atherectomy Products Market, Share by Supplier

Exhibit 4-16:  2006, Selected Catheter-Directed Thrombolysis Systems

Exhibit 4-17:  Peripheral Catheter-Directed Thrombolysis Products, Market Forecast, 2004-2009

Exhibit 4-18:  2004, Catheter-Directed Thrombolysis Products Market, Share by Supplier

Exhibit 4-19:  2006, Selected Peripheral Mechanical Thrombectomy Systems

Exhibit 4-20:  Peripheral Mechanical Thrombectomy Systems, Market Forecast, 2004-2009

Exhibit 4-21:  2004, Peripheral Mechanical Thrombectomy Systems Market, Share by Supplier

Exhibit 4-22:  2006, Selected Peripheral Endovascular Embolization Products

Exhibit 4-23:  Peripheral Endovascular Embolization Products, Market Forecast, 2004-2009

Exhibit 4-24:  2004, Peripheral Endovascular Embolization Products Market, Share by Supplier

Exhibit 4-25:  2006, Selected Vena Cava Filter Systems

Exhibit 4-26:  Vena Cava Filter Systems, Market Forecast, 2004-2009

Exhibit 4-27:  2004, Vena Cava Filter Systems Market, Share by Supplier

Exhibit 4-28:  2006, Selected Vascular Puncture Closure Systems

Exhibit 4-29:  Peripheral Intervention-Related Vascular Puncture Closure Systems, Market Forecast, 2004-2009

Exhibit 4-30:  2004, Peripheral Intervention-Related Vascular Puncture Closure Systems Market, Share by Supplier

Exhibit 4-31:  Peripheral Interventions Involving Novel and Emerging Techniques, Procedure Volumes Forecast, 2004-2009

Exhibit 4-32:  Novel and Emerging Peripheral Interventional Therapy Products, Market Forecast, 2004-2009

Exhibit 4-33:  Peripheral Cryoplasty Products, Market Forecast, 2004-2009

Exhibit 4-34:  2006, Selected Powered Peripheral Chronic Total Occlusion Crossing Products

Exhibit 4-35:  Powered Peripheral Chronic Total Occlusion Crossing Products, Market Forecast, 2004-2009

Exhibit 4-36:  2004, Powered Peripheral Chronic Total Occlusion Crossing Products Market, Share by Supplier

Exhibit 4-37:  Selected Peripheral Angiogenic Therapy Products under Development

Exhibit 4-38:  Peripheral Therapeutic Angiogenesis Products, Market Forecast, 2004-2009

5. COMPANY PROFILES

5.1   Abbott Vascular Devices, Inc./Abbott Laboratories

5.2   AngioDynamics, Inc.

5.3   Arrow International, Inc.

5.4   Bard Peripheral Vascular, Inc./C.R. Bard, Inc.

5.5   BioSphere Medical, Inc.

5.6   Boston Scientific Corporation

5.7   B. Braun Melsungen AG

5.8   Cook Group, Inc.

5.9   Cordis Corporation/Johnson & Johnson

5.10 CryoCath Technologies, Inc.

5.11 Datascope Corporation

5.12 ev3, Inc.         

5.13 FoxHollow Technologies, Inc.

5.14 LuMend, Inc./Cordis Corporation/Johnson & Johnson

5.15 Possis Medical, Inc

5.16 Spectranetics Corporation

5.17 St. Jude Medical, Inc.

5.18 Volcano Therapeutics, Inc.

APPENDIX:  COMPANY LISTING

Copyright 2006, Medtech Insight, LLC