|
TABLE OF CONTENTS
AND LIST OF EXHIBITS
EXECUTIVE SUMMARY
i. European Healthcare Markets
ii. Biomaterials in Arthroscopic Surgery Applications
iii. Bioresorbable Tissue Fixation Devices
iv. Arthroscopic Suturing Devices
a. Suture Anchors
b. Meniscal Repair
Devices
v. Viscosupplementation Products
vi. Autologous Cultured Chondrocytes
Exhibit ES-1:
Europe, Biomaterials-Based Arthroscopy Products, Market
Forecast, By Segment, 2004-2010
Exhibit ES-2:
European Union, Population Statistics Comparison, 1995 and 2005
Exhibit ES-3:
Europe, Bioresorbable Fixation Products, Combined Market
Forecast, 2004-2010
Exhibit ES-4:
Europe, Bioresorbable Fixation Products, Market
Forecast, By Country, 2004-2010
Exhibit ES-5:
Europe, Arthroscopic Suturing Devices, Market Forecast,
By Country, 2004-2010
Exhibit ES-6:
Europe, Arthroscopic Suture Anchors, Combined Market
Forecast, 2004-2010
Exhibit ES-7:
Europe, Meniscal Repair Devices, Combined Market
Forecast, 2004-2010
Exhibit ES-8:
Europe, Viscosupplementation, Combined Market Forecast,
2004-2010
Exhibit ES-9:
Europe, Viscosupplementation Products, Market Forecast,
By Country, 2004-2010
Exhibit ES-10:
Europe, Autologous Cultured Chondrocytes, Combined
Market Forecast, 2004-2010
Exhibit ES-11:
Europe, Autologous Cultured Chondrocytes, Market
Forecast, By Country, 2004-2010
1. EUROPEAN
HEALTHCARE MARKET OVERVIEW
1.1 The European
Union
1.1.1 A Common Currency
1.1.2 Regulatory Policies
1.1.3 Reimbursement
1.1.4 Factors Affecting Healthcare Delivery
1.1.4.1 Aging Population
1.1.4.2 Cost Containment
1.1.4.3 Industry Consolidation
1.1.4.4 Managed Care
1.1.5 Healthcare Spending
1.1.6 Hospital
Services
1.2 Selected
European National Healthcare Profiles
1.2.1
France
1.2.1.1 Healthcare Organization and Reform
1.2.1.2 Hospital
Services
1.2.1.3 Medical Device Reimbursement
1.2.2
Germany
1.2.2.1 Healthcare Organization and Reform
1.2.2.2 Hospital
Services
1.2.2.3 Medical Device Reimbursement
1.2.3
Italy
1.2.3.1 Healthcare Organization and Reform
1.2.3.2 Hospital
Services
1.2.3.3 Medical Device Reimbursement
1.2.4
Spain
1.2.4.1 Healthcare Organization and Reform
1.2.4.2 Hospital
Services
1.2.4.3 Medical Device Reimbursement
1.2.5
United Kingdom
1.2.5.1 Healthcare Organization and Reform
1.2.5.2 Hospital
Services
1.2.5.3 Medical Device Reimbursement
1.2.6 Rest of
Europe
1.2.6.1 Healthcare Organization and Reform
Exhibit 1-1:
European Union, Medical Devices Risk Classification System
Exhibit 1-2:
European Union, Population Statistics Comparison, 1995 and 2005
Exhibit 1-3:
France, Selected National Healthcare Statistics
Exhibit 1-4:
Germany, Selected National Healthcare Statistics
Exhibit 1-5:
Italy, Selected National Healthcare Statistics
Exhibit 1-6:
Spain, Selected National Healthcare Statistics
Exhibit 1-7:
United Kingdom, Selected National Healthcare Statistics
Exhibit 1-8:
2003, Key Health System Characteristics of New European Union Member
States
2. MUSCULOSKELETAL
SYSTEM OVERVIEW
2.1 Bone Structure
and Function
2.1.1 Cellular Framework
2.1.1.1 Osteoblasts
2.1.1.2 Osteocytes
2.1.1.3 Osteoclasts
2.1.1.4 Osteogenesis
2.1.2 Bone Tissue
2.1.2.1 Cancellous and Cortical Bone Tissue
2.1.2.2 Bone Marrow
2.1.3 Bone Anatomy
2.1.3.1 Diaphysis and Epiphysis
2.1.3.2 Endosteum
2.1.3.3 Periosteum
2.1.4 Joint Components
2.1.4.1 Cartilage
2.1.4.1.1 Elastic Cartilage
2.1.4.1.2 Fibrocartilage
2.1.4.1.3 Hyaline Cartilage
2.1.4.2 Bursae
2.1.4.3 Joint Cavity
2.1.4.4 Menisci
2.1.4.5 Synovial Membrane and Fluid
2.1.4.6 Ligaments and Tendons
2.1.4.7 Muscles
2.1.5 Joint Structures
2.1.5.1 Ankle
2.1.5.2 Digits
2.1.5.3 Elbow
2.1.5.4 Hip
2.1.5.5 Knee
2.1.5.6 Shoulder
2.1.5.7 Wrist
2.1.6 Bone Formation and Remodeling
2.1.6.1 In the Fetus
2.1.6.2 In Childhood
2.1.6.3 In Adulthood
2.1.6.4 In Old Age
2.1.6.5 Mechanical Stress and Wolff’s Law
2.1.7 Factors Affecting Bone Physiology
2.1.7.1 Age
2.1.7.2 Gender
2.1.7.3 Genetic Disposition
2.1.7.4 Hormonal Activity
2.1.7.5 Physical Activity
2.1.7.6 Cigarette Smoking
2.1.7.7 Alcohol and Caffeine Intake
2.1.7.8 Nutritional Deficiencies
2.2 Joint Structure
and Function
2.2.1 Types of Joints
2.2.1.1 Synarthroses
2.2.1.2 Amphiarthroses
2.2.1.3 Diarthroses
2.2.1.3.1 Ball-and-Socket
2.2.1.3.2 Condyloid
2.2.1.3.3 Hinge
2.2.1.3.4 Gliding
2.2.1.3.5 Pivot
2.2.2 Arthritis
2.2.2.1 Osteoarthritis
2.2.2.2 Rheumatoid Arthritis
2.3 Management of
Joint Disorders
2.3.1 Joint Replacement
2.3.1.1 Dislocation
2.3.1.2 Ligament and Tendon Injuries
2.3.1.3 Meniscal Injuries
2.3.2 Arthroscopy
Exhibit 2-1:
Illustration of Bone Tissue
Exhibit 2-2:
Types of Cartilage
3. BIOMATERIALS IN ORTHOPEDIC
AND
ARTHROSCOPIC SURGERY APPLICATIONS
3.1 Introduction to
Biomaterials
3.1.1 Definition of Biomaterials
3.1.2 Biomaterial Sources
3.1.2.1
Biomaterials Derived from Living Tissues
3.1.2.2 Synthetic
Biomaterials
3.1.2.2.1 Organic
3.1.2.2.2 Inorganic
3.1.2.3 Hybrid
Biomaterials
3.1.3 Properties of Biomaterials
3.1.3.1
Nonresorbable Biomaterials
3.1.3.2 Resorbable
and Soluble Biomaterials
3.1.3.3 Host Tissue
Response
3.1.4 Tissue
Engineering and the Use of Biomaterial Scaffolds
3.1.4.1 Scaffolds
for Bone Tissue Regeneration/Repair
3.1.4.2 Scaffolds
for Cartilage Tissue Regeneration/Repair
3.1.4.3 Scaffolds
for Meniscal Tissue Regeneration/Repair
3.1.4.4 Tissue
Engineering Techniques and Bone Growth Factors
3.1.4.5 Tissue
Engineering Techniques and Gene Therapy
3.2 Reconstructive
Materials
3.2.1 Metals
3.2.1.1 Cobalt
Alloys
3.2.1.1.1 Structure and Properties
3.2.1.1.2 Host Tissue Response
3.2.1.1.3
Advantages and Disadvantages
3.2.1.2 Stainless
Steel Alloys
3.2.1.2.1 Structure
and Properties
3.2.1.2.2 Host
Tissue Response
3.2.1.2.3
Advantages and Disadvantages
3.2.1.3 Titanium
Alloys
3.2.1.3.1 Structure
and Properties
3.2.1.3.2 Host
Tissue Response
3.2.1.3.3
Advantages and Disadvantages
3.2.2 Ceramics
3.2.2.1 Aluminum
Oxides
3.2.2.1.1 Structure
and Properties
3.2.2.2
Hydroxyapatite/Calcium Phosphates
3.2.2.3 Structure
and Properties
3.2.2.4 Bioactive
Glasses
3.2.2.4.1 Structure
and Properties
3.2.2.4.2 Host
Tissue Response
3.2.2.4.3
Advantages and Disadvantages
3.2.3 Polymers
3.2.3.1 Carbon
Fiber
3.2.3.1.1 Structure
and Properties
3.2.3.2 Silicone
Rubber
3.2.3.2.1 Structure
and Properties
3.2.3.3
Polyethylene
3.2.3.3.1 Structure
and Properties
3.2.3.4
Polytetrafluoroethylene
3.2.3.4.1 Structure
and Properties
3.2.3.5
Polyurethanes
3.2.3.5.1 Structure and Properties
3.2.3.6 Ultra-High
Molecular-Weight Polyethylene
3.2.3.6.1 Structure and Properties
3.2.3.7 Host Tissue
Response
3.2.3.8 Advantages
and Disadvantages
3.3 Resorbable
Materials
3.3.1 Polyglycolic Acid
3.3.2 Polylactic Acid
3.3.3 Copolymers
Exhibit 3-1:
2006, Selected Synthetic Biomaterials Used in Tissue Engineering and
Organ Replacement/Regeneration Applications
Exhibit 3-2:
American Society for Testing and Materials, Document 1418, Silicone
Rubber Classifications
4. ARTHROSCOPIC
SURGERY PRODUCTS MARKETS
4.1 Arthroscopic
Surgery
4.1.1 Articular Surface Repair
4.1.2 Ligament Repair
4.1.3 Meniscal Repair
4.1.4 Tendon Repair
4.2 Bioresorbable
Tissue Fixation Devices
4.2.1 Indications for Use
4.2.2 Products/Technologies
4.2.3 Market Forecasts
4.2.3.1
France
4.2.3.2
Germany
4.2.3.3
Italy
4.2.3.4
Spain
4.2.3.5
United Kingdom
4.2.3.6 Rest of
Europe
4.2.4 Competitive Analysis
4.2.4.1
France
4.2.4.2
Germany
4.2.4.3
Italy
4.2.4.4
Spain
4.2.4.5
United Kingdom
4.2.4.6 Rest of
Europe
4.3 Arthroscopic
Suturing Devices
4.3.1 Suture Anchors
4.3.1.1 Products/Technologies
4.3.1.2 Market Analysis
4.3.2 Meniscal Repair Devices
4.3.2.1 Products/Technologies
4.3.2.2 Market Analysis
4.3.3 Market Forecasts
4.3.3.1
France
4.3.3.2
Germany
4.3.3.3
Italy
4.3.3.4
Spain
4.3.3.5
United Kingdom
4.3.3.6 Rest of
Europe
4.3.4 Competitive Analysis
4.3.4.1
France
4.3.4.2
Germany
4.3.4.3
Italy
4.3.4.4
Spain
4.3.4.5
United Kingdom
4.3.4.6 Rest of
Europe
4.4
Viscosupplementation Products
4.4.1 Hyaluronic Acid Formulations
4.4.2 Products/Technologies
4.4.3 Market Forecasts
4.4.3.1
France
4.4.3.2
Germany
4.4.3.3
Italy
4.4.3.4
Spain
4.4.3.5
United Kingdom
4.4.3.6 Rest of
Europe
4.4.4 Competitive Analysis
4.4.4.1
France
4.4.4.2
Germany
4.4.4.3
Italy
4.4.4.4
Spain
4.4.4.5
United Kingdom
4.4.4.6 Rest of
Europe
4.5 Autologous
Cultured Chondrocytes
4.5.1 Indications for Use
4.5.2 Harvesting Procedures
4.5.3 Culturing Procedures
4.5.4 Implantation Procedures
4.5.5 Products/Technologies
4.5.6 Market Forecasts
4.5.6.1
France
4.5.6.2
Germany
4.5.6.3
Italy
4.5.6.4
Spain
4.5.6.5
United Kingdom
4.5.6.6 Rest of
Europe
4.5.7 Competitive Analysis
4.5.7.1
France
4.5.7.2
Germany
4.5.7.3
Italy
4.5.7.4
Spain
4.5.7.5
United Kingdom
4.5.7.6 Rest of
Europe
Exhibit 4-1:
Treatment Options for Anterior Cruciate Ligament Repair
Exhibit 4-2:
Treatment Options for Meniscal Injury Repair
Exhibit 4-3:
Types of Bioresorbable Fixation Devices
Exhibit 4-4:
2006, Selected Bioresorbable Bone Screws, Nails, Pins, and Tacks
Exhibit 4-5:
2006, Selected Bioresorbable Interference Screws
Exhibit 4-6:
Europe, Bioresorbable Fixation Products, Combined Market Forecast,
2004-2010
Exhibit 4-7:
Europe, Bioresorbable Fixation Products, Market Forecast, By Country,
2004-2010
Exhibit 4-8:
France, Bioresorbable Fixation Products, Market Forecast, 2004-2010
Exhibit 4-9:
Germany, Bioresorbable Fixation Products, Market Forecast, 2004-2010
Exhibit 4-10:
Italy, Bioresorbable Fixation Products, Market Forecast, 2004-2010
Exhibit 4-11:
Spain, Bioresorbable Fixation Products, Market Forecast, 2004-2010
Exhibit 4-12:
United Kingdom, Bioresorbable Fixation Products, Market Forecast,
2004-2010
Exhibit 4-13:
Rest of Europe, Bioresorbable Fixation Products, Market Forecast,
2004-2010
Exhibit 4-14:
2005, Europe, Bioresorbable Fixation Products Market, Share by
Supplier
Exhibit 4-15:
2005, France, Bioresorbable Fixation Products Market, Share by
Supplier
Exhibit 4-16:
2005, Germany, Bioresorbable Fixation Products Market, Share by
Supplier
Exhibit 4-17:
2005, Italy, Bioresorbable Fixation Products Market, Share by Supplier
Exhibit 4-18:
2005, Spain, Bioresorbable Fixation Products Market, Share by Supplier
Exhibit 4-19:
2005, United Kingdom, Bioresorbable Fixation Products Market, Share by
Supplier
Exhibit 4-20:
2005, Rest of Europe, Bioresorbable Fixation Products Market, Share by
Supplier
Exhibit 4-21:
2006, Selected Bioresorbable Suture Anchors
Exhibit 4-22:
Europe, Arthroscopic Suture Anchors, Combined Market
Forecast, 2004-2010
Exhibit 4-23:
2006, Selected Bioresorbable Meniscal Repair Devices
Exhibit 4-24:
Europe, Meniscal Repair Devices, Combined Market
Forecast, 2004-2010
Exhibit 4-25:
Europe, Arthroscopic Suturing Devices, Market Forecast,
By Country, 2004-2010
Exhibit 4-26:
France, Arthroscopic Suturing Devices, Market Forecast, 2004-2010
Exhibit 4-27:
Germany, Arthroscopic Suturing Devices, Market Forecast, 2004-2010
Exhibit 4-28:
Italy, Arthroscopic Suturing Devices, Market Forecast, 2004-2010
Exhibit 4-29:
Spain, Arthroscopic Suturing Devices, Market Forecast, 2004-2010
Exhibit 4-30:
United Kingdom, Arthroscopic Suturing Devices, Market Forecast,
2004-2010
Exhibit 4-31:
Rest of Europe, Arthroscopic Suturing Devices, Market Forecast,
2004-2010
Exhibit 4-32:
2005, Europe, Arthroscopic Suturing Devices Market, Share by Supplier
Exhibit 4-33:
2005, France, Arthroscopic Suturing Devices Market, Share by Supplier
Exhibit 4-34:
2005, Germany, Arthroscopic Suturing Devices Market, Share by Supplier
Exhibit 4-35:
2005, Italy, Arthroscopic Suturing Devices Market, Share by Supplier
Exhibit 4-36:
2005, Spain, Arthroscopic Suturing Devices Market, Share by Supplier
Exhibit 4-37:
2005, United Kingdom, Arthroscopic Suturing Devices Market, Share by
Supplier
Exhibit 4-38:
2005, Rest of Europe, Arthroscopic Suturing Devices Market, Share by
Supplier
Exhibit 4-39:
2006, Selected Current and Emerging Viscosupplementation Products
Exhibit 4-40:
Europe, Viscosupplementation, Combined Market Forecast,
2004-2010
Exhibit 4-41:
Europe, Viscosupplementation Products, Market Forecast,
By Country, 2004-2010
Exhibit 4-42:
France, Viscosupplementation Products, Market Forecast, 2004-2010
Exhibit 4-43:
Germany, Viscosupplementation Products, Market Forecast, 2004-2010
Exhibit 4-44:
Italy, Viscosupplementation Products, Market Forecast, 2004-2010
Exhibit 4-45:
Spain, Viscosupplementation Products, Market Forecast, 2004-2010
Exhibit 4-46:
United Kingdom, Viscosupplementation Products, Market Forecast,
2004-2010
Exhibit 4-47:
Rest of Europe, Viscosupplementation Products, Market Forecast,
2004-2010
Exhibit 4-48:
2005, Europe, Viscosupplementation Products Market, Share by Supplier
Exhibit 4-49:
2005, France, Viscosupplementation Products Market, Share by Supplier
Exhibit 4-50:
2005, Germany, Viscosupplementation Products Market, Share by Supplier
Exhibit 4-51:
2005, Italy, Viscosupplementation Products Market, Share by Supplier
Exhibit 4-52:
2005, Spain, Viscosupplementation Products Market, Share by Supplier
Exhibit 4-53:
2005, United Kingdom, Viscosupplementation Products Market, Share by
Supplier
Exhibit 4-54:
2005, Rest of Europe, Viscosupplementation Products Market, Share by
Supplier
Exhibit 4-55:
2006, Selected Autologous Cultured Chondrocyte Products
Exhibit 4-56:
Europe, Autologous Cultured Chondrocytes, Combined
Market Forecast, 2004-2010
Exhibit 4-57:
Europe, Autologous Cultured Chondrocytes, Market
Forecast, By Country, 2004-2010
Exhibit 4-58:
France, Autologous Cultured Chondrocytes, Market Forecast, 2004-2010
Exhibit 4-59:
Germany, Autologous Cultured Chondrocytes, Market Forecast, 2004-2010
Exhibit 4-60:
Italy, Autologous Cultured Chondrocytes, Market Forecast, 2004-2010
Exhibit 4-61:
Spain, Autologous Cultured Chondrocytes, Market Forecast, 2004-2010
Exhibit 4-62:
United Kingdom, Autologous Cultured Chondrocytes, Market Forecast,
2004-2010
Exhibit 4-63:
Rest of Europe, Autologous Cultured Chondrocytes, Unit Volumes and
Market Forecast, 2004-2010
Exhibit 4-64:
2005, Europe, Autologous Cultured Chondrocytes Market, Share by
Supplier
Exhibit 4-65:
2005, France, Autologous Cultured Chondrocytes Market, Share by
Supplier
Exhibit 4-66:
2005, Germany, Autologous Cultured Chondrocytes Market, Share by
Supplier
Exhibit 4-67:
2005, Italy, Autologous Cultured Chondrocytes Market, Share by
Supplier
Exhibit 4-68:
2005, Spain, Autologous Cultured Chondrocytes Market, Share by
Supplier
Exhibit 4-69:
2005, United Kingdom, Autologous Cultured Chondrocytes Market, Share
by Supplier
Exhibit 4-70:
2005, Rest of Europe, Autologous Cultured Chondrocytes Market, Share
by Supplier
5. COMPANY PROFILES
5.1 Anika
Therapeutics, Inc.
5.2 ARS ARTHRO
AG
5.3 Arthrex,
Inc.
5.4
Biocomposites
LTD
5.5 Biomet,
Inc.
5.6 Bioniche
Life Sciences, Inc.
5.7 BioTissue
Technologies GmbH/The BioTissue Group
5.8 co.don AG
5.9 ConMed
Corporation
5.10 Genzyme
Corporation
5.11 Interface
Biotech
AS
5.12 Johnson &
Johnson
5.13
Regeneration Technologies, Inc.
5.14 Smith &
Nephew PLC
5.15 Stryker
Corporation
5.16 TETEC AG
5.17 Tyco
International LTD
APPENDIX: COMPANY
LISTING
Copyright 2006,
Medtech Insight, LLC |
