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U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration
Report #A322
- July 2013
231 Pages – 66 Exhibits – 10 Company Profiles


In the United States (U.S.), aging baby boomers are causing an increase in the prevalence of osteoarthritis and other degenerative joint disorders. In addition, the large and growing Millennial generation is contributing to an increasing number of sports-related injuries.

This dynamic new report from Medtech Insight includes analyses of products, competitors, and opportunities in the U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration. This market, as covered by the scope of this report, comprises bioresorbable fixation devices (pins, screws, tacks, and suture anchors), cartilage repair and regeneration technologies (cell-based approaches, cell-free scaffolds, and gene therapy), ligament and tendon repair/replacement/ regeneration products (traditional sports medicine allografts and gene and cell-based therapies, platelet-rich plasma, scaffolds, and synthetic growth factors), meniscal repair/regeneration/replacement technologies (allografts, bioresorbable fixation devices, and scaffolding and cell therapy technologies), and viscosupplementation products (hyaluronic acid-based therapies). During the forecast period covered by this report, the combined U.S. market for orthopedic biomaterials for viscosupplementation and cartilage, ligament/tendon, and meniscal repair and regeneration is projected to reach an estimated value of $1.9 billion in the year 2017.

This is the second of two Medtech Insight reports covering the U.S. market for orthopedic biomaterials. Report #A321, "U.S. Markets for Orthopedic Biomaterials for Bone Repair and Regeneration," was published in May 2013.

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U.S. Markets for Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration

A322

July 2013

$3,750

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Methodology

Reports are produced exclusively by Medtech Insight, through extensive primary and secondary research among the clinicians, researchers, and competitors in the marketplace, and draw upon the industry expertise of a network of industry insiders. Medtech Insight exhaustively corroborates the data as a baseline for completing forward-looking analysis and providing insight into product, technology and market evolution.

 

TABLE OF CONTENTS

 

EXECUTIVE SUMMARY

i.          Bioresorbable Fixation Devices

ii.          Viscosupplementation

iii.         Cartilage Repair and Regeneration

iv.         Meniscal Repair, Regeneration, and Replacement

a.      Bioresorbable Fixation Devices

b.      Meniscal Allografts

v.         Ligament and Tendon Repair, Regeneration, and Replacement

vi.         Combined Market Forecast

vii.        Methodology

 

Exhibit ES-1:    Types of Bioresorbable Fixation Devices

Exhibit ES-2:    Bioresorbable Fixation Devices, Market Forecast, 2012-2017

Exhibit ES-3:    Viscosupplementation Products, Market Forecast, 2012-2017

Exhibit ES-4:    Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017

Exhibit ES-5:    Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017

Exhibit ES-6:    Ligament and Tendon Allografts, Market Forecast, 2012-2017

Exhibit ES-7:    Orthopedic Biomaterials for Viscosupplementation and Cartilage, Ligament/Tendon, and Meniscal Repair and Regeneration, Combined Market Forecast, 2012-2017

 

1. MUSCULOSKELETAL SYSTEM OVERVIEW

1.1 Bone Structure and Function

1.1.1 Cellular Framework

1.1.1.1 Osteoblasts

1.1.1.2 Osteocytes

1.1.1.3 Osteoclasts

1.1.1.4 Osteogenesis

1.1.2 Bone Tissue

1.1.2.1 Cancellous and Cortical Bone Tissue

1.1.2.2 Bone Marrow

1.1.3 Bone Anatomy

1.1.3.1 Diaphysis and Epiphysis

1.1.3.2 Endosteum

1.1.3.3 Periosteum

1.1.4 Joint Components

1.1.4.1 Cartilage

1.1.4.1.1 Elastic Cartilage

1.1.4.1.2 Fibrocartilage

1.1.4.1.3 Hyaline Cartilage

1.1.4.2 Bursae

1.1.4.3 Joint Cavity

1.1.4.4 Menisci

1.1.4.5 Synovial Membrane and Fluid

1.1.4.6 Ligaments and Tendons

1.1.4.7 Muscles

1.1.5 Joint Structures

1.1.5.1 Ankle

1.1.5.2 Digits

1.1.5.3 Elbow

1.1.5.4 Hip

1.1.5.5 Knee

1.1.5.6 Shoulder

1.1.5.7 Wrist

1.1.6 Bone Formation and Remodeling

1.1.6.1 In the Fetus

1.1.6.2 In Childhood

1.1.6.3 In Adulthood

1.1.6.4 In Old Age

1.1.6.5 Mechanical Stress and Wolff’s Law

1.1.7 Factors Affecting Bone Physiology

1.1.7.1 Age

1.1.7.2 Gender

1.1.7.3 Genetic Disposition

1.1.7.4 Hormonal Activity

1.1.7.5 Physical Activity

1.1.7.6 Cigarette Smoking

1.1.7.7 Alcohol and Caffeine Intake

1.1.7.8 Nutritional Deficiencies

1.2 Joint Structure and Function

1.2.1 Types of Joints

1.2.1.1 Synarthroses

1.2.1.2 Amphiarthroses

1.2.1.3 Diarthroses

1.2.1.3.1 Ball-and-Socket

1.2.1.3.2 Condyloid

1.2.1.3.3 Hinge

1.2.1.3.4 Gliding

1.2.1.3.5 Pivot

1.2.2 Arthritis

1.2.2.1 Osteoarthritis

1.2.2.2 Rheumatoid Arthritis

1.3 Management of Joint Disorders

1.3.1 Joint Replacement

1.3.1.1 Dislocation

1.3.1.2 Ligament and Tendon Injuries

1.3.1.3 Meniscal Injuries

 

Exhibit 1-1:      Illustration of Bone Tissue

Exhibit 1-2:      Types of Cartilage

Exhibit 1-3:      Stages of Bone Remodeling

 

2. BIORESORBABLE FIXATION DEVICES

2.1 Materials

2.2 Products

2.2.1 Bioresorbable Pins

2.2.2 Bioresorbable Screws, Nails, and Tacks

2.2.3 Bioresorbable Interference Screws

2.2.4 Bioresorbable Suture Anchors

2.2.5 Bioresorbable Meniscal Repair Devices

2.3 Market Analysis

2.4 Competitive Analysis

 

Exhibit 2-1:      Advantages of Bioresorbable Fixation Devices

Exhibit 2-2:      Factors Affecting the Properties of Bioresorbable Polymers

Exhibit 2-3:      Types of Bioresorbable Fixation Devices

Exhibit 2-4:      2013, Selected Bioresorbable Pins

Exhibit 2-5:      2013, Selected Bioresorbable Nails, Screws, and Tacks

Exhibit 2-6:      2013, Selected Bioresorbable Interference Screws

Exhibit 2-7:      2013, Selected Bioresorbable Suture Anchors

Exhibit 2-8:      2013, Selected Bioresorbable Meniscal Repair Devices

Exhibit 2-9:      Bioresorbable Fixation Devices,  Market Forecast, 2012-2017

Exhibit 2-10:    2012, Bioresorbable Fixation Devices Market, Share by Supplier

 

3. VISCOSUPPLEMENTATION

3.1 Osteoarthritis Clinical Overview

3.2 Viscosupplementation Therapy

3.3 Products

3.3.1 Anika Therapeutics

3.3.2 Ferring Pharmaceuticals

3.3.3 Fidia Pharma USA/Fidia Farmaceutici

3.3.4 Genzyme/Sanofi

3.3.5 Seikagaku

3.3.6 Smith & Nephew

3.4 Emerging Products

3.5 Potential Viscosupplementation Patients

3.6 Product Reimbursement

3.7 Market Analysis

3.8 Competitive Analysis

 

Exhibit 3-1:      2013, Administerers of Hyaluronic Acid Injection Therapy, by Specialty

Exhibit 3-2:      2013, Selected Viscosupplementation Products

Exhibit 3-3:      2013, Selected Emerging Viscosupplementation Therapies

Exhibit 3-4:      2012, Patients with Knee Osteoarthritis

Exhibit 3-5:      Projected Incidence of Symptomatic Knee Osteoarthritis, by 10-Year Age Group

Exhibit 3-6:      Historical and Future Annual Growth Rates in the Elderly Population

Exhibit 3-7:      Viscosupplementation Products, Market Forecast, 2012-2017

Exhibit 3-8:      2012, Viscosupplementation Products Market, Share by Supplier

 

4. CARTILAGE REPAIR AND REGENERATION

4.1 Clinical Overview

4.2 Products

4.2.1 Cell-Based Approaches

4.2.1.1 Chondrocyte Transplantation

4.2.1.1.1 Anika Therapeutics

4.2.1.1.2 BioTissue Technologies

4.2.1.1.3 DePuy Mitek/Johnson & Johnson

4.2.1.1.4 Geistlich Pharma

4.2.1.1.5 Genzyme/Sanofi

4.2.1.1.6 ProChon Biotech/Histogenics

4.2.1.1.7 Sanofi

4.2.1.1.8 TETEC/B. Braun Melsungen

4.2.1.1.9 TiGenix

4.2.1.1.10 Allogeneic Juvenile Chondrocytes

4.2.1.2 Stem Cells

4.2.1.2.1 Geron

4.2.1.2.2 Medipost

4.2.1.2.3 Mesoblast

4.2.1.2.4 Smith & Nephew

4.2.1.3 Growth Factor Technology

4.2.1.3.1 BioMimetic Therapeutics/Wright Medical Group

4.2.1.3.2 EMD Serono/Merck

4.2.1.3.3 Sanofi

4.2.1.3.4 TissueGene

4.2.2 Cell-Free Composites and Scaffolds

4.2.2.1 Anika Therapeutics

4.2.2.2 Arthro Kinetics

4.2.2.3 Biomet

4.2.2.4 BioTissue

4.2.2.5 Cartiva

4.2.2.6 Cytex

4.2.2.7 Histogenics

4.2.2.8 Kensey Nash/Royal DSM

4.2.2.9 Piramal Healthcare

4.2.2.10 Regentis Biomaterials

4.2.2.11 Smith & Nephew

4.3 Reimbursement

4.4 Market Analysis

4.5 Competitive Analysis

 

Exhibit 4-1:      The Outerbridge Classification System for Chondral Defects

Exhibit 4-2:      Arthroscopic Knee Surgery, Procedure Volumes Forecast, 2012-2017

Exhibit 4-3:      2012, Cartilage Repair Procedures

Exhibit 4-4:      Genzyme’s Carticel Autologous Chondrocyte Implantation Device

Exhibit 4-5:      2013, Selected Chondrocyte Graft Products and Technologies

Exhibit 4-6:      2013, Selected Emerging Stem Cell-Based Products for Cartilage Repair

Exhibit 4-7:      2013, Selected Emerging Recombinant Human Growth Factor Products

Exhibit 4-8:      2013, Selected Cell-Free Scaffolds for Cartilage Repair and Regeneration

Exhibit 4-9:      Cartilage Repair and Regeneration Products, Market Forecast, 2012-2017

Exhibit 4-10:    Cartilage Regeneration, Potential Procedure Volumes Forecast, 2012-2017

 

5. MENISCAL REPAIR, REGENERATION, AND REPLACEMENT

5.1 Clinical Overview

5.1.1 Meniscal Injuries

5.1.1.1 Traumatic Tears

5.1.1.2 Degenerative Tears

5.2 Current Treatment

5.2.1 Nonoperative Treatment

5.2.2 Surgical Treatment

5.2.2.1 Arthroscopic Suturing

5.2.2.2 Bioresorbable Fixation

5.2.2.3 Meniscectomy

5.3 Procedure Volumes

5.4 Meniscal Repair and Regeneration

5.4.1 Bioresorbable Fixation Products

5.4.2 Market Analysis

5.4.3 Competitive Analysis

5.5 Meniscal Replacement

5.5.1 Meniscal Allografts

5.5.2 Market Analysis

5.5.3 Competitive Analysis

5.6 Meniscal Repair, Regeneration, and Replacement Technologies Under Development

5.6.1 Scaffolding Technologies

5.6.1.1 Collagen

5.6.1.2 Fibrin

5.6.1.3 Polymers

5.6.2 Cell Therapy

5.7 Combined Market Forecast

 

Exhibit 5-1:      Anatomy of the Knee Joint

Exhibit 5-2:      Common Types of Meniscal Tears

Exhibit 5-3:      Illustration of a Meniscal Tear

Exhibit 5-4:      Comparison of Treatment Options for Meniscal Injuries

Exhibit 5-5:      Meniscectomy and Meniscal Repair, Procedure Volumes Forecast, 2012-2017

Exhibit 5-6:      2013, Selected Bioresorbable Fixation Devices for Meniscal Repair

Exhibit 5-7:      Bioresorbable Fixation Devices for Meniscal Repair, Market Forecast, 2012-2017

Exhibit 5-8:      2012, Market for Bioresorbable Fixation Devices for Meniscal Repair, Share by Supplier

Exhibit 5-9:      2013, Selected Meniscal Allografts

Exhibit 5-10:    Meniscal Allografts, Market Forecast, 2012-2017

Exhibit 5-11:    2012, Meniscal Allografts Products Market, Share by Supplier

Exhibit 5-12:    2013, Selected Meniscal Scaffolding Products Under Development

Exhibit 5-13:    Chondrogen Phase I/II Clinical Trial Results

Exhibit 5-14:    Meniscal Repair, Regeneration, and Replacement Products, Combined Market Forecast, 2012-2017

 

6. LIGAMENT AND TENDON REPAIR, REGENERATION, AND REPLACEMENT

6.1 Clinical Overview

6.1.1 The Knee

6.1.2 The Achilles Tendon

6.1.3 Hand Ligaments and Tendons

6.1.4 Shoulder Ligaments and Tendons

6.2 Procedure Volumes

6.3 Current Treatments

6.3.1 Anterior Cruciate Ligament Tears

6.3.2 Rotator Cuff Tears

6.4 Allografts

6.5 Tissue Engineering

6.5.1 Biologic Scaffolds

6.5.2 Polymer-Based Scaffolds

6.6 Growth Factors

6.6.1 Platelet-Rich Plasma

6.6.2 Synthetic Growth Factors

6.7 Cell and Gene Therapies

6.7.1 Cell-Based Therapies Under Development

6.8 Market Analysis

6.9 Competitive Analysis

6.10 Ligament and Tendon Replacement Market Status

6.11 Emerging Ligament and Tendon Regeneration Products Market

 

Exhibit 6-1:      Anatomy of the Knee Joint

Exhibit 6-2:      Anterior Cruciate Ligament Injury

Exhibit 6-3:      Achilles Tendon Rupture

Exhibit 6-4:      Ligaments of the Shoulder

Exhibit 6-5:      2012, Ligament and Tendon Procedures, by Anatomic Location

Exhibit 6-6:      2013, Selected Allografts for Ligament and Tendon Replacement

Exhibit 6-7:      2013, Selected Tissue-Engineered Ligament and Tendon Repair Products

Exhibit 6-8:      2013, Selected Collagen-Based Scaffolds Under Development for Ligament and Tendon Repair

Exhibit 6-9:      2013, Selected Synthetic Scaffolds Under Development for Ligament and Tendon Repair

Exhibit 6-10:    Aperion Biologics’ Z-Lig Xenograft

Exhibit 6-11:    2013, Selected Growth Factor Products and Technologies Under Development

Exhibit 6-12:    2013, Selected Cell-Based Therapy Approaches Under Development for Tendon Repair

Exhibit 6-13:    Ligament and Tendon Allografts, Market Forecast, 2012-2017

Exhibit 6-14:    2012, Ligament and Tendon Allografts Market, Share by Supplier

 

7. COMPANY PROFILES

7.1       Arthrex, Inc.

7.2       ConMed Linvatec/ConMed Corporation

7.3       Fidia Pharma USA, Inc./Fidia Farmaceutici SpA

7.4       Genzyme Corporation/Sanofi SA

7.5       Johnson & Johnson

7.6       LifeNet Health, Inc.

7.7       Medtronic, Inc.

7.8       Musculoskeletal Transplant Foundation, Inc.

7.9       RTI Biologics, Inc.

7.10     Smith & Nephew PLC

 

APPENDIX:  COMPANY LISTING

 

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