TABLE OF CONTENTS

EXECUTIVE SUMMARY

i.  Sports Injuries in the United States

ii.  Conservative Care Products

iii. Arthroscopic Equipment

iv. Surgical Implants

v. Combined Market Analysis

1. SPORTS INJURIES IN THE UNITED STATES

1.1 Sprains and Strains

1.1.1 Sprains

1.1.2 Strains

1.1.3 Symptoms

1.1.4 Treatment

1.2 Dislocations and Fractures

1.2.1 Dislocations

1.2.2 Fractures

1.2.3 Symptoms

1.2.4 Treatment

1.3 Knee Injuries

1.3.1 Damaged Cartilage

1.3.1.1 Causes

1.3.1.2 Symptoms

1.3.1.3 Treatment

1.3.2 Torn Meniscus

1.3.2.1 Causes

1.3.2.2 Symptoms

1.3.2.3 Treatment

1.3.3 Torn Cruciate Ligament

1.3.3.1 Causes

1.3.3.2 Symptoms

1.3.3.3 Treatment

1.3.4 Torn Collateral Ligament

1.3.4.1 Causes

1.3.4.2 Symptoms

1.3.4.3 Treatment

1.4 Shoulder Injuries

1.4.1 Torn Rotator Cuff

1.4.1.1 Causes

1.4.1.2 Symptoms

1.4.1.3 Treatment

1.4.2 Superior Labrum Lesion

1.4.2.1 Causes

1.4.2.2 Symptoms

1.4.2.3 Treatment

1.5 Muscle and Tendon Tears and Avulsions

1.5.1 Causes

1.5.2 Symptoms

1.5.3 Treatment

2. CONSERVATIVE CARE

2.1 Bandages, Splints, and Wraps

2.2 Braces

2.2.1 Functional Knee Braces

2.2.2 Custom Knee Braces

2.2.3 Back and Neck Braces

2.2.4 Other Braces

2.3 Heat and Cold Therapy

2.4 Medications and Injections

2.4.1 Over-the-Counter Medications

2.4.2 Prescription Medications

2.4.3 Corticosteroid Injections

2.5 Nutriceuticals

2.6 Synovial Fluid Replacement

2.6.1 Hyaluronic Acid Injection Therapy

3. SURGICAL PROCEDURES OVERVIEW

3.1 Arthroscopic Knee Surgery

3.1.1 Cartilage Repair

3.1.1.1 Surgical Treatments

3.1.2 Cartilage Regeneration

3.1.3 Meniscal Repair

3.1.3.1 Nonoperative Treatment

3.1.3.2 Meniscectomy

3.1.3.3 Arthroscopic Suturing

3.1.3.4 Meniscal Replacement

3.1.4 Cruciate Ligament Reconstruction

3.1.4.1 Autografts

3.1.4.1.1 Bone-Patella-Bone Graft

3.1.4.1.2 Hamstring Tendon Graft

3.1.4.1.3 Quadriceps Tendon Graft

3.1.4.2 Allografts

3.1.4.2.1 Scaffolding

3.1.4.2.2 Collagen Scaffolds

3.1.4.2.3 Acellular Tissue Matrices

3.1.4.2.4 Synthetic Scaffolds

3.1.5 Growth Factors and Genes

3.2 Arthroscopic Shoulder Surgery

3.2.1 Acromioclavicular Joint Resection

3.2.2 Rotator Cuff Repair

3.2.3 Thermal Capsulorrhaphy

3.2.4 Recurrent Shoulder Dislocation

3.2.5 Bankart Repair

3.2.6 Superior Labrum Anterior to Posterior Lesion Repair

3.3 Other Arthroscopic Procedures

3.3.1 Arthroscopic Elbow Procedures

3.3.2 Arthroscopic Wrist Procedures

3.3.3 Arthroscopic Ankle Procedures

3.4 Open Surgical Procedures

3.4.1 Achilles Tendon Repair

3.4.2 Biceps Tendon Repair

3.4.3 Gamekeeper’s Thumb Repair

4. CONSERVATIVE CARE PRODUCTS

4.1 Bandages, Splints, and Wraps

4.1.1 Bandages

4.1.2 Splints

4.1.3 Wraps

4.1.4 Competitive Analysis

4.2 Braces

4.2.1 Products

4.2.2 Competitive Analysis

4.3 Heat and Cold Therapy

4.3.1 Fixed and Portable Systems

4.3.2 Hot/Cold Packs

4.3.3 Competitive Analysis

4.4 Medications and Injections

4.4.1 Products

4.4.2 Competitive Analysis

4.5 Nutriceuticals

4.5.1 Products

4.5.2 Competitive Analysis

4.6 Synovial Fluid Replacement

4.6.1 Hyaluronic Acid

4.6.1.1 Anika Therapeutics

4.6.1.2 Fidia Pharmaceuticals

4.6.1.3 Genzyme

4.6.1.4 Seikagaku

4.6.1.5 Vitrolife

4.6.2 Other Synovial Fluid Replacement Products

4.6.3 Competitive Analysis

5. ARTHROSCOPIC EQUIPMENT

5.1 Complete Operating Room Systems

5.2 Arthroscopic Visualization

5.2.1 Arthroscopes

5.2.1.1 Disposable Arthroscopes

5.2.1.2 Reusable Arthroscopes

5.2.1.3 Small-Diameter Arthroscopes

5.2.2 Cameras

5.2.3 Video Equipment

5.2.3.1 Light Sources

5.2.3.2 Video Monitors

5.2.4 Competitive Analysis

5.3 Fluid Management

5.3.1 Products

5.3.2 Competitive Analysis

5.4 Manual Instruments

5.4.1 Products

5.4.2 Competitive Analysis

5.5 Powered Instruments

5.5.1 Blades and Cutting Instruments

5.5.2 Fluidjet Instruments

5.5.3 Radiofrequency Instruments

5.5.4 Competitive Analysis

6. SURGICAL IMPLANTS

6.1 Tissue Scaffolds and Grafts

6.1.1 Cartilage

6.1.1.1 Cellular Regeneration

6.1.1.1.1 Chondrocyte Transplantation

6.1.1.1.2 Stem Cell Technology

6.1.1.1.3 Growth Factor Technology

6.1.1.2 Scaffolds

6.1.1.2.1 Polymer

6.1.1.2.2 Collagen

6.1.1.2.3 Other

6.1.1.3 Cartilage Resurfacing

6.1.2 Meniscus

6.1.2.1 Meniscal Allografts

6.1.2.2 Scaffolding Technologies

6.1.2.2.1 Collagen

6.1.2.2.2 Polymer

6.1.2.2.3 Biological

6.1.2.3 Gene and Cell Therapy

6.1.3 Ligaments and Tendons

6.1.3.1 Allograft Transplants

6.1.3.2 Scaffolds and Gene Factors

6.1.3.2.1 Acellular

6.1.3.2.2 Collagen

6.1.3.2.3 Polymer

6.1.3.3 Growth Factors and Genes

6.1.3.3.1 Tissue Patches

6.2 Market Analysis

6.2.1 Cartilage Repair and Regeneration

6.2.2 Meniscal Replacement and Regeneration

6.2.3 Ligament and Tendon Repair and Replacement

6.2.4 Meniscal Fixation Devices

6.2.4.1 Nonresorbable Devices

6.2.4.2 Bioesorbable Devices

6.2.4.3 Competitive Analysis

6.2.5 Cruciate Ligament Fixation Devices

6.2.5.1 Interference Screws

6.2.5.2 Nonresorbable Interference Screws

6.2.5.3 Bioresorbable Interference Screws

6.2.5.4 Graft Suspension Devices

6.2.5.5 Competitive Analysis

6.2.6 Shoulder Fixation Devices

6.2.6.1 Nonresorbable Anchors

6.2.6.2 Bioresorbable Anchors

6.2.6.3 Biologic Anchors

6.2.6.4 Bone Screws and Tacks

6.2.6.5 Soft-Tissue Reinforcing Plates

6.2.7 Competitive Analysis

6.2.8 Combined Market Forecast

7. COMPANY PROFILES

7.1   Arthrex, Inc.

7.2   ArthroCare Corporation

7.3   C.R. Bard, Inc.

7.4   Bayer AG

7.5   Biomet, Inc.

7.6   Breg, Inc.

7.7   Cardinal Health, Inc.

7.8   ConMed Corporation

7.9   CryoLife, Inc.

7.10 dj Orthopedics, Inc.

7.11 Encore Medical Corporation

7.12 Genzyme Corporation

7.13 Johnson & Johnson

7.14 Olympus America, Inc./Olympus Optical Company LTD

7.15 Opus Medical, Inc.

7.16 ReGen Biologics, Inc.

7.17 Regeneration Technologies, Inc.

7.18 Royal Numico NV

7.19 Smith & Nephew PLC

7.20 Karl Storz Endoscopy-America, Inc./Karl Storz GbmH

7.21 Stryker Corporation

7.22 Tutogen Medical, Inc.

7.23 Zimmer, Inc.

APPENDIX:  COMPANY LISTING

LIST OF EXHIBITS

Exhibit ES-1:  Conservative Care Products, Market Forecast, 2001-2010

Exhibit ES-2:  Arthroscopic Equipment, Market Forecast, 2001-2010

Exhibit ES-3:  Surgical Implants, Market Forecast, 2001-2010

Exhibit ES-4:  Sports Medicine Products, Market Forecast, 2001-2010

Exhibit 1-1:    Incidence of Nonfatal Sports-Related Injuries, by Age and Gender, July 2000-June 2001

Exhibit 1-2:    Signs and Symptoms of a Sprain

Exhibit 1-3:    Signs and Symptoms of a Strain

Exhibit 1-4:    Risks Factors for Sprains and Strains

Exhibit 1-5:    Nonoperative Treatments for Rotator Cuff Tears

Exhibit 1-6:    Operative Treatments for Rotator Cuff Tears       

Exhibit 2-1:    Risks Associated with Splint Use

Exhibit 2-2:    Guidelines for Selecting a Proper Knee Brace

Exhibit 2-3:    2003, Selected Prescription Analgesics and Nonsteroidal Anti-Inflammatory Drugs

Exhibit 2-4:    Advatages and Disadvantages of Hyaluronic Acid Injection Therapy

Exhibit 2-5:    2001, Hyaluronic Acid Injection Therapy Providers, by Specialty

Exhibit 3-1:    Causes of Articular Cartilage Injury

Exhibit 3-2:    Outerbridge Classification System for Chondral Damage

Exhibit 3-3:    Prognostic Factors for Arthroscopic Debridement of the Knee

Exhibit 3-4:    2001, Cartilage-Related Knee Arthroscopies, Procedure Volumes, by Type  

Exhibit 3-5:    Survey Results of Treatment Approaches for Isolated Chondral Defects

Exhibit 3-6:    Expected Future Use of Treatments for Isolated Chondral Defects

Exhibit 3-7:    Comparison of Treatment Options for Meniscal Injuries

Exhibit 3-8:    Surgical Options for Anterior Cruciate Ligament Repair

Exhibit 3-9:    Survey Results of Treatment Approaches for Anterior Cruciate Ligament Reconstruction

Exhibit 3-10:  Survey Results for Treatment Approaches for Rotator Cuff Repair

Exhibit 3-11:  Survey Results for Treatment Approaches for Recurrent Shoulder Instability

Exhibit 3-12:  Conditions Amenable to Arthroscopic Wrist Surgery

Exhibit 3-13:  Conditions Amenable to Arthroscopic Ankle Surgery

Exhibit 4-1:    Splints and Wraps, Market Forecast, 2001-2010

Exhibit 4-2:    2001, Splints and Wraps Market, Share by Supplier

Exhibit 4-3:    Functional Braces, Market Forecast, 2001-2010

Exhibit 4-4:    2001, Functional Braces Market, Share by Supplier

Exhibit 4-5:    Heat and Cold Therapy Products, Market Forecast, 2001-2010

Exhibit 4-6:    2001, Heat and Cold Therapy Products Market, Share by Supplier

Exhibit 4-7:    Over-the-Counter Pain Management Drugs, Market Forecast, 2001-2010

Exhibit 4-8:    2001, Over-the-Counter Pain Management Drugs Market, Share by Supplier

Exhibit 4-9:    Non-Narcotic Prescription Pain Management Drugs, Market Forecast, 2001-2010

Exhibit 4-10:  2001, Non-Narcotic Prescription Pain Management Drugs Market, Share by Supplier

Exhibit 4-11:  Chondroitin Sulfate and Glucosamine, Market Forecast, 2001-2010

Exhibit 4-12:  2001, Chondroitin Sulfate and Glucosamine Market, Share by Supplier

Exhibit 4-13:  2003, Selected Current and Emerging Synovial Fluid Replacement Products

Exhibit 4-14:  Synovial Fluid Replacement Products, Market Forecast, 2001-2010       

Exhibit 4-15:  2001, Synovial Fluid Replacement Products Market, Share by Supplier

Exhibit 5-1:    2003, Selected Standard Arthroscopes

Exhibit 5-2:    2003, Selected Small-Diameter Arthroscopes

Exhibit 5-3:    2003, Selected Arthroscopic Video Cameras

Exhibit 5-4:    Arthroscopic Visualization Products, Market Forecast, 2001-2010

Exhibit 5-5:    2001, Arthroscopic Visualization Products Market, Share by Supplier

Exhibit 5-6:    2003, Selected Arthroscopic Fluid Management Products

Exhibit 5-7:    Arthroscopic Fluid Management Products, Market Forecast, 2001-2010

Exhibit 5-8:    2001, Arthroscopic Fluid Management Products Market, Share by Supplier

Exhibit 5-9:    Arthroscopic Manual Instruments, Market Forecast, 2001-2010

Exhibit 5-10:  2001, Arthroscopic Manual Instruments Market, Share by Supplier

Exhibit 5-11:  2003, Selected Arthroscopic Blades and Cutting Instruments

Exhibit 5-12:  2003, Selected Arthroscopic Radiofrequency Instruments

Exhibit 5-13:  Arthroscopic Powered Instruments, Market Forecast, 2001-2010

Exhibit 5-14:  2001, Arthroscopic Powered Instruments Market, Share by Supplier

Exhibit 6-1:    2003, Selected Companies Offering Cartilage Repair and Replacement Products       

Exhibit 6-2:    2003, Selected Current and Emerging Chondrocyte Transplantation Products

Exhibit 6-3:    2003, Selected Stem Cell-Based Products for Cartilage Repair

Exhibit 6-4:    2003, Selected Emerging Polymer-Based Scaffolds for Cartilage Repair

Exhibit 6-5:    2003, Selected Emerging Collagen-Based Scaffolds for Cartilage Repair

Exhibit 6-6:    2003, Selected Emerging Other Scaffold Materials for Cartilage Repair

Exhibit 6-7:    2003, Selected Emerging Cartilage Resurfacing Products

Exhibit 6-8:    2003, Selected Meniscal Replacement Products

Exhibit 6-9:    2003, Selected Emerging Meniscal Replacement Scaffolding Products

Exhibit 6-10:  2003, Selected Ligament and Tendon Allografts

Exhibit 6-11:  2003, Selected Emerging Acellular Tissue Scaffolds for Ligament and Tendon Repair

Exhibit 6-12:  2003, Selected Emerging Collagen-Based Scaffolds for Ligament and Tendon Repair

Exhibit 6-13:  2003, Selected Emerging Polymer-Based Scaffolds for Ligament and Tendon Repair

Exhibit 6-14:  2003, Selected Emerging Growth Factor Technologies for Ligament and Tendon Repair

Exhibit 6-15:  Cartilage Repair and Regeneration, Procedure Volumes Forecast, 2001-2010

Exhibit 6-16:  Cartilage Regeneration Products, Market Forecast, 2001-2010

Exhibit 6-17:  Meniscal Replacement Products, Market Forecast, 2001-2010

Exhibit 6-18:  Ligament and Tendon Replacement Products, Market Forecast, 2001-2010

Exhibit 6-19:  2001, Ligament and Tendon Replacement Products Market, Share by Supplier

Exhibit 6-20:  2003, Selected Resorbable Polymer-Based Devices for Meniscal Repair

Exhibit 6-21:  Meniscal Fixation Products, Market Forecast, 2001-2010

Exhibit 6-22:  2001, Meniscal Fixation Products Market, Share by Supplier

Exhibit 6-23:  2003, Selected Bioresorbable Interference Screws

Exhibit 6-24:  Cruciate Ligament Fixation Devices, Market Forecast, 2001-2010

Exhibit 6-25:  2001, Cruciate Fixation Devices Market, Share by Supplier

Exhibit 6-26:  2003, Selected Bioresorbable Suture Anchors

Exhibit 6-27:  2003, Selected Bioresorbable Bone Screws and Tacks

Exhibit 6-28:  Shoulder Fixation Devices, Market Forecast, 2001-2010

Exhibit 6-29:  2001, Shoulder Fixation Devices Market, Share by Supplier        

Exhibit 6-30:  Sports Medicine Surgical Implants, Market Forecast, 2001-2010

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