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U.S. Markets for Pharmacologic and Device-Based Approaches to Pain Management
Report #A374
- June 2014
192 Pages – 43 Exhibits – 17 Company Profiles


Pain is the single most common reason patients seek medical care, accounting for approximately half of all physician office visits in the United States (U.S.); some studies suggest that more than one-third of people in the U.S. suffer from a chronic pain condition at some point in their lives.

This dynamic new report from Medtech Insight includes analyses of products, current/forecast markets, competitors, and opportunities in the U.S. market for pain management products. Product areas covered by the scope of this report include pain management pharmaceuticals (e.g., nonprescription analgesics and anesthetics including systemic and topical formulations, as well as prescription analgesics and anesthetics including prescription NSAIDs, opioid analgesics, opioid/nonopioid combination analgesics, antimigraine analgesics, adjuvant analgesics, and general/regional/local anesthetics) and pain management devices (e.g., electrical stimulators including TENS systems and neurostimulators, as well as analgesia infusion pumps including implantable and external models).

During the forecast period covered by this report, the combined U.S. market for pain management products is projected to increase from $36.4 billion in 2013 to $44.7 billion in the year 2018. Pain management pharmaceuticals account for more than 92% of total sales, with pain management devices accounting for the remaining 8% of sales.

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Date
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U.S. Markets for Pharmacologic and Device-Based Approaches to Pain Management

A374

June 2014

$4,750

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Methodology

Reports are produced exclusively by Medtech Insight, through extensive primary and secondary research among the clinicians, researchers, and competitors in the marketplace, and draw upon the industry expertise of a network of industry insiders. Medtech Insight exhaustively corroborates the data as a baseline for completing forward-looking analysis and providing insight into product, technology and market evolution.

 

TABLE OF CONTENTS

 

EXECUTIVE SUMMARY

i.       Pain Management Pharmaceuticals

a.         Nonprescription Analgesics and Anesthetics

i.          Nonprescription Systemic Analgesics

ii.          Nonprescription Topical Analgesics

iii.         Market Forecast

b.         Prescription Analgesics and Anesthetics

i.          Prescription Non-Steroidal Anti-Inflammatory Drugs

ii.          Opioid Analgesics

iii.         Opioid/Nonopioid Combination Analgesics

iv.         Antimigraine Analgesics

v.         Adjuvant Analgesics

vi.         General, Regional, and Local Anesthetics

vii.        Market Forecast

c.          Combined Market Forecast

ii.       Pain Management Devices

a.         Electrical Stimulators

i.          Transcutaneous Electrical Nerve Stimulators

ii.          Neurostimulators

iii.         Market Forecast

b.         Analgesia Infusion Pumps

i.          Implantable Analgesia Infusion Pumps

ii.          External Analgesia Infusion Pumps

iii.         Market Forecast

c.          Combined Market Forecast

iii.      Combined Market Forecast

 

Exhibit ES-1:..... Nonprescription Analgesics/Anesthetics, Market Share, by Product Segment,
2013 and 2018

Exhibit ES-2:..... Prescription Analgesics/Anesthetics, Market Share, by Product Segment, 2013 and 2018

Exhibit ES-3:..... Pain Management Pharmaceuticals, Combined Market Share, by Product Segment, 2013 and 2018

Exhibit ES-4:..... Electrical Stimulators, Market Share,
by Product Segment, 2013 and 2018

Exhibit ES-5:..... Analgesia Infusion Pumps, Market Share,
by Product Segment, 2013 and 2018

Exhibit ES-6:..... Pain Management Devices, Combined Market Share, by Product Segment, 2013 and 2018

Exhibit ES-7:..... Pain Management Pharmaceuticals and Devices, Combined Market Share,
by Product Segment, 2013 and 2018

 

1.         Pain Management Overview

1.1     Pain Physiology

1.1.1     The Nervous System

1.1.2     Pain Perception

1.1.3     Pain Classification

1.1.3.1  Nociceptive Pain

1.1.3.2  Non-Nociceptive Pain

1.1.3.3  Acute Pain

1.1.3.4  Chronic Pain

1.2     Pain Assessment Techniques

1.3     Pain Prevalence

1.4     Common Pain Syndromes

1.4.1     Arthritis Pain

1.4.2     Back Pain

1.4.3     Burn Pain

1.4.4     Cancer Pain

1.4.5     Headache Pain

1.4.6     Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome Pain

1.4.7     Obstetric Pain

1.4.8     Podiatric Pain

1.4.9     Sciatic Pain

1.4.10   Temporomandibular Pain

1.4.11   Trauma Pain

1.5     Clinical Approaches to Pain Management

1.5.1     Pain Management Guidelines

1.5.2     Pain Management Guidelines for Older Adults

1.5.3     Interventional Pain Management Guidelines

1.5.4     Pain Management Options

1.5.4.1  Pharmaceutical Options

1.5.4.2  Device-Based Options

1.5.4.3  Alternative Therapy Options

 

Exhibit 1-1:....... Common Causes of Neuropathic Pain

Exhibit 1-2:....... United States Population, by Selected Ages, 1990-2050

Exhibit 1-3:....... Overview of the Joint Commission’s Standards for Pain Assessment and Management

 

2.         PAIN MANAGEMENT PHARMACEUTICALS

2.1     Pharmaceutical Formulations and Drug Delivery

2.1.1     Oral Drug Delivery

2.1.2     Injection/Infusion Drug Delivery

2.1.2.1  Injection

2.1.2.1.1  Intramuscular Injection

2.1.2.1.2  Subcutaneous Injection

2.1.2.2  Infusion

2.1.2.2.1  Intravenous Infusion

2.1.2.2.2  Intraspinal Infusion

2.1.2.2.3  Intraoperative Site Infusion

2.1.3     Inhalation Drug Delivery

2.1.4     Transdermal Drug Delivery

2.1.5     Transmucosal Drug Delivery

2.1.6     Nonsteroidal Anti-Inflammatory Drugs

2.1.6.1  Heart Attack and Hypertension Risks

2.1.6.2  The Food and Drug Administration and Labeling

2.1.6.3  Naproxen Risks

2.2     The Benefits of Aspirin

2.2.1     Aspirin and Heart Attack/Stroke Prevention

2.2.2     Aspirin and Heart Failure

2.2.3     Aspirin and Cancer Prevention

2.3     Market Analysis

2.3.1     Nonprescription Analgesics and Anesthetics

2.3.1.1  Market Forecast

2.3.1.2  Nonprescription Systemic Analgesics

2.3.1.2.1  Acetaminophen

2.3.1.2.2  Nonprescription Nonsteroidal Anti-Inflammatory Drugs

2.3.1.2.2.1  Aspirin

2.3.1.2.2.2  Ibuprofen

2.3.1.2.2.3  Ketoprofen

2.3.1.2.2.4  Naproxen

2.3.1.2.3  Market Forecast

2.3.1.2.4  Competitive Analysis

2.3.1.3  Nonprescription Topical Analgesics and Anesthetics

2.3.1.3.1  Amino Amides and Esters

2.3.1.3.2  Capsaicin

2.3.1.3.3  Methyl and Trolamine Salicylates

2.3.1.3.4  Topical Patches

2.3.1.3.5  Market Forecast

2.3.1.3.6  Competitive Analysis

2.3.2     Prescription Analgesics and Anesthetics

2.3.2.1  Market Forecast

2.3.2.2  Prescription Nonsteroidal Anti-Inflammatory Drugs

2.3.2.2.1  Acetic Acid Derivatives

2.3.2.2.2  Anthranilic Acid Derivatives

2.3.2.2.3  Cyclooxygenase-2 Selective Inhibitors

2.3.2.2.4  Enolic Acid Derivatives

2.3.2.2.5  Propionic Acid Derivatives

2.3.2.2.6  Salicylic Acid Derivatives

2.3.2.2.7  Market Forecast

2.3.2.2.8  Competitive Analysis

2.3.2.3  Opioid Analgesics

2.3.2.3.1  Buprenorphine

2.3.2.3.2  Butorphanol

2.3.2.3.3  Codeine

2.3.2.3.4  Fentanyl

2.3.2.3.5  Hydromorphone

2.3.2.3.6  Levorphanol

2.3.2.3.7  Meperidine

2.3.2.3.8  Morphine

2.3.2.3.9  Nalbuphine

2.3.2.3.10 Oxycodone

2.3.2.3.11 Oxymorphone

2.3.2.3.12 Pentazocine

2.3.2.3.13 Propoxyphene

2.3.2.3.14 Remifentanil

2.3.2.3.15 Tramadol

2.3.2.3.16 Tapentadol

2.3.2.3.17 Hydrocodone

2.3.2.3.18 Market Forecast

2.3.2.3.19 Competitive Analysis

2.3.2.4  Opioid/Nonopioid
Combination Analgesics

2.3.2.4.1  Market Forecast

2.3.2.4.2  Competitive Analysis

2.3.2.5  Antimigraine Analgesics

2.3.2.5.1  Diclofenac

2.3.2.5.2  Dihydroergotamine

2.3.2.5.3  Divalproex Sodium

2.3.2.5.4  Triptans

2.3.2.5.5  Market Forecast

2.3.2.5.6  Competitive Analysis

2.3.2.6  Adjuvant Analgesics

2.3.2.6.1  Anticonvulsants

2.3.2.6.2  Antidepressants

2.3.2.6.3  Corticosteriods

2.3.2.6.4  Market Forecast

2.3.2.6.5  Competitive Analysis

2.3.2.7  General, Regional, and Local Anesthetics

2.3.2.7.1  Inhalation General Anesthetics

2.3.2.7.2  Intravenous General Anesthetics

2.3.2.7.3  Anesthetics Used in Balanced Anesthesia

2.3.2.7.4  Regional/Local Anesthetics

2.3.2.7.5  Market Forecast

2.3.2.7.6  Competitive Analysis

2.3.3     Combined Market Forecast

 

Exhibit 2-1:....... Advantages and Disadvantages of
Common Drug Delivery Methods

Exhibit 2-2:....... 2014, Selected Nonprescription
Analgesics and Anesthetics

Exhibit 2-3:....... 2014, Selected Prescription
Analgesics and Anesthetics

Exhibit 2-4:....... Nonprescription Analgesics and Anesthetics, Market Forecast 2013-2018

Exhibit 2-5:....... Nonprescription Systemic Analgesics,
Market Forecast, 2013-2018

Exhibit 2-6:....... 2013, Nonprescription Systemic Analgesics Market, Share by Supplier

Exhibit 2-7:....... Nonprescription Topical Analgesics/Anesthetics, Market Forecast, 2013-2018

Exhibit 2-8:....... 2013, Nonprescription Topical Analgesics/Anesthetics Market,
Share by Supplier

Exhibit 2-9:....... Prescription Analgesics and Anesthetics, Market Forecast, 2013-2018

Exhibit 2-10:..... Prescription Nonsteroidal Anti-Inflammatory Drugs, Market Forecast, 2013-2018

Exhibit 2-11:..... 2013, Prescription Nonsteroidal Anti-Inflammatory Drugs Market,
Share by Supplier

Exhibit 2-12:..... Prescription Opioid Analgesics,
Market Forecast, 2013-2018

Exhibit 2-13:..... 2013, Prescription Opioid Analgesics Market, Share by Supplier

Exhibit 2-14:..... Prescription Opioid/Nonopioid Combination Analgesics, Market Forecast, 2013-2018

Exhibit 2-15:..... Prescription Antimigraine Analgesics,
Market Forecast, 2013-2018

Exhibit 2-16:..... 2013, Prescription Antimigraine Analgesics Market, Share by Supplier

Exhibit 2-17:..... Prescription Adjuvant Analgesics,
Market Forecast, 2013-2018

Exhibit 2-18:..... 2013, Prescription Adjuvant Analgesics Market, Share by Supplier

Exhibit 2-19:..... General, Regional, and Local Anesthetics, Market Forecast, 2013-2018

Exhibit 2-20:..... 2013, General, Regional, and Local Anesthetics Market, Share by Supplier

Exhibit 2-21:..... Pain Management Pharmaceuticals, Combined Market Forecast, 2013-2018

 

3.         PAIN MANAGEMENT DEVICES

3.1     Electrical Stimulators

3.1.1     Transcutaneous Electrical Nerve Stimulators

3.1.1.1  Market Forecast

3.1.1.2  Competitive Analysis

3.1.2     Neurostimulators

3.1.2.1  Occipital Nerve Stimulation

3.1.2.2  Neuromuscular Stimulators

3.1.2.3  Spinal Cord and Peripheral Nerve Stimulators

3.1.2.4  Market Forecast

3.1.2.6  Competitive Analysis

3.2     Analgesia Infusion Pumps

3.2.1     Implantable Analgesia Infusion Pumps

3.2.1.1  Market Forecast

3.2.1.2  Competitive Analysis

3.2.2     External Analgesia Infusion Pumps

3.2.2.1  Nerve Block

3.2.2.2  Patient-Controlled Analgesia Infusion Pumps

3.2.2.3  Products

3.2.2.4  Market Forecast

3.2.2.5  Competitive Analysis

3.3     Combined Market Forecast

 

Exhibit 3-1:....... Proposed Fourth Step of the World Health Organization Analgesic Ladder

Exhibit 3-2:....... Selected Painful Conditions Appropriate for Electrical Stimulation Therapy

Exhibit 3-3:....... Transcutaneous Electrical Nerve Stimulators, Market Forecast, 2013-2018

Exhibit 3-4:....... 2013, Transcutaneous Electrical Nerve Stimulators Market, Share by Supplier

Exhibit 3-5:....... Neurostimulators, Market Forecast,
2013-2018

Exhibit 3-6:....... 2013, Spinal Cord Stimulators Market,
Share by Supplier

Exhibit 3-7:....... 2013, Neuromuscular Stimulators Market, Share by Supplier

Exhibit 3-8:....... Implantable Analgesia Infusion Pumps,  Market Forecast, 2013-2018

Exhibit 3-9:....... 2013, Implantable Analgesia Infusion Pumps Market, Share by Supplier

Exhibit 3-10:..... External Analgesia Infusion Pumps,
Market Forecast, 2013-2018

Exhibit 3-11:..... 2013, External Analgesia Infusion Pumps Market, Share by Supplier

Exhibit 3-12:..... Pain Management Devices,
Combined Market Forecast, 2013-2018

 

4.         Company profiles

4.1     AstraZeneca PLC

4.2     Baxter Healthcare, Inc./Baxter International, Inc.

4.3     Bayer HealthCare AG/Bayer AG

4.4     Boston Scientific Corporation

4.5     CareFusion Corporation

4.6     Chattem, Inc./sanofi-aventis LLC

4.7     DJO Global, Inc.

4.8     Eli Lilly and Company

4.9     Endo Pharmaceutical Holdings, Inc./Endo International PLC

4.10   GlaxoSmithKline PLC

4.11   Hospira, Inc.

4.12   International Rehabilitative Sciences, Inc.,
d/b/a RS Medical

4.13   Johnson & Johnson

4.14   Medtronic, Inc.

4.15   Pfizer, Inc.

4.16   Purdue Pharma LP

4.17   Teva Pharmaceutical Industries LTD

 

appendix:  company lisTIng

 

 

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