Directed energy-based surgical therapy employs the controlled deposition of energy into targeted tissues to achieve a desired tissue alteration.  This relatively new surgical area includes cryotherapy, laser energy, microwave energy, photodynamic therapy, radiofrequency, and ultrasound. 

This report focuses on the nine major surgical areas where directed energy-based techniques are prominent and growing, including:  cardiovascular therapy, cosmetic (aesthetic) applications, dentistry, gynecological surgery, head and neck surgery, oncology, orthopedic surgery, ophthalmic surgery, and urology.

The U.S. directed energy-based surgical market is growing at a fast pace.  This is due to the significantly reduced cost, operative trauma, tissue damage and blood loss, reduced risk of infection, shorter hospital and recovery time and precision in targeted tissue alteration.  In 2003, directed energy-based therapy was employed in nearly 19.2 million procedures in the U.S., generating over $2.2 billion in cumulative product sales.  Over a short timeframe of only five years, this market is expected gain sales of nearly $1.8 billion, reaching sales of over $4.0 billion by the year 2008. 

Of the directed energy-based segments, the largest segments in 2003 were ophthalmic and orthopedic surgery, respectively, with cumulative sales of nearly $1.4 billion, or approximately 60% of the total market.  The aesthetic and urologic markets followed, contributing estimated sales of over $474 million, or 20% of the total market.  The smaller cardiovascular, dental, gynecology and oncology segments, however, will demonstrate the fastest relative growth over the next five years.

This dynamic report from Medtech Insight includes analyses directed-energy based equipment and presents competitors, current and forecast markets, and opportunities.  Covered topics include:  bone stimulator technology, cryotherapy, electro-optical synergy, endovascular sonotherapy, extracorporeal shockwave therapy, focused ultrasound, global endometrial ablation, laser in situ keratomileusis, medical lasers (alexandrite, carbon dioxide, diode, excimer, pulsed dye, ruby and yttrium-aluminum-garnet), nonablative skin rejuvenation therapy, photodynamic therapy, photorefractive keratectomy, radiofrequency, transpupillary thermotherapy photocoagulation, transurethral microwave thermotherapy, transmyocardial revascularization, and ultrasound-based phacoemulsification.

TABLE OF CONTENTS
 

EXECUTIVE SUMMARY

i.      Aesthetics

ii.     Cardiovascular

iii.    Dentistry

iv.    Gynecology

v.     Head and Neck

vi.    Oncology

vii.   Ophthalmology

viii.   Orthopedics

ix.    Urology

1. OVERVIEW OF DIRECTED ENERGY-BASED SURGICAL SYSTEMS

1.1 Cryoablation

1.1.1 Therapeutic Applications

1.2 Focused Ultrasound Technology

1.2.1 Therapeutic Applications

1.3 Lasers

1.3.1 Types of Medical Lasers

1.3.1.1 Alexandrite Lasers

1.3.1.2 Argon Lasers

1.3.1.3 Carbon Dioxide Lasers

1.3.1.4 Copper Vapor Lasers

1.3.1.5 Diode Lasers

1.3.1.6 Excimer Lasers

1.3.1.7 Pulsed Dye Lasers

1.3.1.8 Ruby Lasers

1.3.1.9 Yttrium-Aluminum-Garnet Lasers

1.3.2 Absorption Characteristics

1.3.2.1 Tissue Evaporation and Coagulation

1.3.3 Therapeutic Applications

1.4 Microwave Energy Technology

1.4.1 Therapeutic Applications

1.5 Photodynamic Therapy

1.5.1 Therapeutic Applications

1.6 Radiofrequency

1.6.1 Therapeutic Applications

2. AESTHETIC APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

2.1 Directed Energy-Based Hair Reduction

2.1.1 Hair Production and Growth

2.1.2 Temporary Hair Removal

2.1.3 Electrolysis

2.1.4 Laser- and Other Light-Based Permanent Hair Reduction

2.1.4.1 Laser Hair Reduction Devices

2.1.4.1.1 Alexandrite Laser Systems

2.1.4.1.2 Diode Laser Systems

2.1.4.1.2.1 Lumenis

2.1.4.1.3 Neodymium Yttrium-Aluminum-Garnet Laser Systems

2.1.4.1.4 Ruby Laser Systems

2.1.4.2 Other Light-Based Hair Reduction Devices

2.1.4.2.1 Syneron

2.1.4.2.2 Radiancy

2.1.4.2.3 Pulsed Light Devices

2.1.4.2.3.1 Lumenis

2.1.4.2.3.2 Palomar Medical Technologies

2.1.4.3 Competitors

2.1.4.4 Procedure Volumes Forecast

2.2 Directed Energy-Based Aesthetic Skin Treatment

2.2.1 Laser Skin Resurfacing

2.2.2 Nonablative Wrinkle Reduction and Skin Rejuvenation

2.2.2.1 Radiofrequency Devices

2.2.2.1.1 Thermage

2.2.2.1.2 Arthrocare

2.2.2.1.3 Gyrus Medical

2.2.2.2 New and Emerging Nonablative Technologies

2.2.2.2.1 Light BioScience

2.2.2.2.2 Other Companies and Technologies

2.2.3 Removal of Benign Skin Lesions

2.2.4 Pitted Acne and Hypertrophic Scarring

2.2.4.1 Lumenis

2.2.4.2 Candela

2.2.4.3 DUSA Pharmaceuticals

2.2.5 Management of Cutaneous Vascular Lesions

2.2.5.1 Hemangioma and Venous Lakes

2.2.5.2 Port Wine Stains

2.2.5.3 Varicose Leg Veins

2.2.5.4 Spider Veins

2.2.6 Competitors

2.3 Procedure Volumes

2.4 Market Analysis

2.5 Competitive Analysis

3. CARDIOVASCULAR APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

3.1 Directed Energy-Based Cardiac Arrhythmia Management

3.1.1 Transcatheter Cardiac Arrhythmia Ablation

3.1.1.1 Products

3.1.1.1.1 Radiofrequency Ablation Devices

3.1.1.1.1.1 Boston Scientific

3.1.1.1.2 Cryoablation Devices

3.1.1.1.2.1 CryoCath Technologies

3.1.1.1.2.2 CryoCor

3.1.1.1.3 Ultrasound Ablation Devices

3.1.1.2 Market Forecast

3.1.1.3 Competitive Analysis

3.1.2 Surgical Cardiac Arrhythmia Ablation

3.1.2.1 Products

3.1.2.1.1 Cryoablation Devices

3.1.2.1.2 Laser Ablation Devices

3.1.2.1.3 Microwave Ablation Devices

3.1.2.1.3.1 Guidant

3.1.2.1.4 Radiofrequency Ablation Devices

3.1.2.1.4.1 AtriCure

3.1.2.1.4.2 Boston Scientific

3.1.2.1.4.3 Cardima

3.1.2.1.4.4 Medtronic

3.1.2.1.5 Ultrasound Ablation Devices

3.1.2.2 Market Forecast

3.1.2.3 Competitive Analysis

3.1.3 Cardiac Rhythm Management Device Lead Extraction

3.1.3.1 Spectranetics

3.1.3.2 Market Analysis

3.2 Directed Energy-Based Reperfusion Therapy

3.2.1 Laser Angioplasty

3.2.1.1 Spectranetics

3.2.1.2 Market Analysis

3.2.2 Anti-Restenosis Therapy

3.2.2.1 Cryotherapy

3.2.2.1.1 CryoVascular Systems

3.2.2.1.2 CryoCath Technologies

3.2.2.2 Endovascular Sonotherapy

3.2.2.2.1 OmniSonics Medical Technologies

3.2.2.2.2 Vascular Solutions

3.2.2.3 Market Analysis

3.2.3 Transmyocardial Revascularization

3.2.3.1 Products

3.2.3.1.1 CardioGenesis

3.2.3.1.2 PLC Medical Systems

3.2.3.2 Market Forecast

3.2.3.3 Competitive Analysis

3.3 Directed Energy-Based Thrombectomy for the Treatment of Acute Ischemic Stroke

4. DENTAL APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

4.1 Laser Applications

4.1.1 Dental Caries

4.1.2 Gingivectomy and Gingivoplasty

4.1.3 Periodontitis

4.1.4 Other Dental Applications

4.2 Dental Lasers

4.2.1 Argon

4.2.2 Carbon Dioxide

4.2.3 Diode

4.2.4 Erbium Yttrium-Aluminum-Garnet

4.2.5 HydroKinetic Erbium

4.2.6 Neodymium Yttrium-Aluminum-Garnet

4.3 Products

4.3.1 BIOLASE Technology

4.3.2 HOYA ConBio/HOYA

4.3.3 OpusDent/Lumenis

4.4 Other Directed Energy-Based Techniques

4.5 Procedure Volumes

4.6 Market Analysis

4.7 Competitive Analysis

5. GYNECOLOGY APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

5.1 Menorrhagia Management

5.1.1 Standard Endometrial Ablation

5.1.2 Global Endometrial Ablation

5.1.2.1 Circulating Heated Saline Systems

5.1.2.1.1 Boston Scientific

5.1.2.2 Cryoablation Systems

5.1.2.2.1 American Medical Systems

5.1.2.3 Hot Water Balloon Systems

5.1.2.3.1 Gynecare

5.1.2.3.2 Wallsten Medical

5.1.2.4 Laser-Based Systems

5.1.2.4.1 Lumenis

5.1.2.5 Microwave Ablation Systems

5.1.2.5.1 Microsulis

5.1.2.6 Radiofrequency Ablation Systems

5.1.2.6.1 Cytyc

5.2 Emerging Transcatheter Sterilization Techniques

5.2.1 Conceptus

5.2.2 Emerging Products

5.3 Fibroma, Polyps, and Other Abnormal Tissue Ablation

5.3.1 Emerging Products

5.3.1.1 InSightec/Elbit Medical Imaging

5.3.1.2 RITA Medical

5.4 Procedure Volumes

5.5 Market Analysis

5.6 Competitive Analysis

6. HEAD AND NECK SURGICAL APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

6.1 Benign Head and Neck Tumors

6.1.1 Laser Treatment

6.1.1.1 Lumenis

6.2 Ear, Nose, and Throat/Upper Airway Obstruction

6.2.1 Adenoidectomy/Tonsillectomy and Turbinate Reduction

6.2.1.1 ArthroCare

6.2.1.2 Lumenis

6.2.2 Sleep Apnea

6.2.2.1 Laser-Assisted Uvuloplasty

6.2.2.1.1 Lumenis

6.2.2.2 Radiofrequency

6.2.2.2.1 Gyrus ENT/Gyrus Group

6.3 Gastroesophageal Reflux Disease

6.3.1 Radiofrequency

6.3.1.1 Curon Medical

6.3.2 Photodynamic Therapy

6.4 Other Laser Applications

6.5 Procedure Volumes

6.6 Market Analysis

6.7 Competitive Analysis

7. ONCOLOGY APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

7.1 Cryoablation

7.1.1 CIMEX BioTech

7.1.2 Endocare

7.1.3 Oncura

7.2 Laser-Based Surgery

7.2.1 Emerging Laser Ablation Techniques

7.2.1.1 Diomed with GE Healthcare/General Electric

7.2.1.2 Monteris Medical

7.2.1.3 Siemens Medical Solutions/Siemens

7.2.1.4 SOMATEX Medical Technologies

7.3 Microwave Ablation

7.3.1 Emerging Microwave Ablation Systems

7.3.1.1 Celsion

7.3.1.2 Microsulis/Microsulis Medical

7.3.1.3 Vivant Medical

7.4 Photodynamic Therapy

7.4.1 Axcan Pharma

7.4.2 Biolitec Pharma/Biolitec

7.4.3 DUSA Pharmaceuticals

7.4.4 PhotoCure

7.4.5 Photonamic/medac

7.5 Radiofrequency Ablation Systems

7.5.1 Boston Scientific

7.5.2 Celsion

7.5.3 RITA Medical Systems

7.5.4 Thermedical

7.5.5 Valleylab/Tyco International

7.6 High-Intensity Focused Ultrasound-Based Surgery

7.6.1 EDAP TMS

7.6.2 Focus Surgery

7.6.3 InSightec/Elbit Medical Imaging

7.7 Procedure Volumes

7.7.1 Cryoablation

7.7.2 Photodynamic Therapy

7.7.3 Radiofrequency

7.8 Market Analysis

7.9 Competitive Analysis

7.9.1 Cryoablation

7.9.2 Photodynamic Therapy

7.9.3 Radiofrequency

8. OPHTHALMOLOGY APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

8.1 Vitreoretinal/Ocular Surgery

8.1.1 Age-Related Macular Degeneration

8.1.1.1 Products

8.1.1.1.1 Photodynamic Therapy

8.1.1.1.1.1 Miravant Medical Technologies

8.1.1.1.1.2 QLT/Novartis

8.1.1.1.2 Retinal Photocoagulation

8.1.1.1.2.1 Lumenis

8.1.1.1.3 Transpupillary Thermotherapy Photocoagulation

8.1.1.1.3.1 IRIDEX

8.1.2 Cataracts

8.1.2.1 Products

8.1.2.1.1 Ultrasound-Based Phacoemulsification

8.1.2.1.2 Laser-Based Cataract Surgery

8.1.2.1.3 Alternative Laser- and Nonthermal-Based Systems

8.1.3 Diabetic Retinopathy

8.1.3.1 Products

8.1.4 Glaucoma

8.1.4.1 Products

8.1.5 Retinal Detachment

8.1.5.1 Products

8.2 Refractive Laser Surgery

8.2.1 Laser-Based Vision Correction

8.2.1.1 Products

8.2.1.1.1 Photorefractive Keratectomy

8.2.1.1.2 Laser In Situ Keratomileusis

8.2.1.1.3 Custom Laser In Situ Keratomileusis

8.2.1.1.3.1 Alcon

8.2.1.1.3.2 Bausch & Lomb

8.2.1.1.3.3 VISX

8.2.1.1.3.4 Other Competitors

8.2.2 New and Emerging Refractive Technology

8.2.2.1 Laser Epithelial Keratomileusis

8.2.2.2 Photoablative Inlay Laser In Situ Keratomileusis

8.2.2.3 Intralase Laser Corneal Flap Creation

8.2.2.4 Radiofrequency-Based Refractive Surgery

8.3 Procedure Volumes

8.3.1 Ocular/Vitreoretinal Surgery

8.3.2 Refractive Surgery

8.4 Market Analysis

8.5 Competitive Analysis

8.5.1 Cataract Surgery

8.5.2 Refractive Laser Surgery

8.5.3 Vitreoretinal Surgery

9. ORTHOPEDIC APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

9.1 Arthroscopy

9.1.1 Clinical Indications for Laser- and Radiofrequency-Based Arthroscopic Surgical Products

9.1.1.1 Ankle, Elbow, and Wrist

9.1.1.2 Hip

9.1.1.3 Knee

9.1.1.4 Shoulder

9.1.2 Products

9.1.2.1 Holmium Lasers

9.1.2.1.1 Lumenis

9.1.2.1.2 Trimedyne

9.1.2.2 Radiofrequency Systems

9.1.2.2.1 ArthroCare

9.1.2.2.2 DePuy Mitek/Johnson & Johnson

9.1.2.2.3 Smith & Nephew

9.2 Spinal Surgery

9.2.1 Disc Herniation and Conventional Treatment

9.2.1.1 Discectomy or Micro-Decompression

9.2.1.2 Laminectomy or Open Decompression

9.2.1.3 Spinal Fusion Surgery

9.2.2 Laser- and Radiofrequency-Based Minimally Invasive Spinal Surgery

9.2.2.1 Laser Systems

9.2.2.2 Radiofrequency Systems

9.2.2.2.1 ArthroCare

9.2.2.2.2 Smith & Nephew

9.2.2.2.3 Valleylab/Tyco International

9.3 Bone Growth Stimulation Systems for Adjunct Healing of Bone Fractures and Spinal Fusion

9.3.1 Products

9.3.1.1 Capacitive Coupling

9.3.1.1.1 EBI/Biomet

9.3.1.2 Combined Magnetic Field

9.3.1.2.1 DePuy Spine/Johnson & Johnson and dj Orthopedics

9.3.1.3 Pulsed Electromagnetic Field-Based Systems

9.3.1.3.1 EBI/Biomet

9.3.1.3.2 Orthofix

9.3.1.4 Low-Intensity, Pulsed Ultrasound Systems

9.3.1.4.1 Smith & Nephew

9.3.1.5 Implantable Direct Current Electrical Stimulation

9.3.1.5.1 EBI/Biomet

9.4 Extracorporeal Shockwave Therapy

9.4.1 Products

9.5 Procedure Volumes

9.5.1 Arthroscopic Surgery

9.5.2 Bone Growth Stimulation

9.5.3 Endoscopic Spinal Surgery

9.5.4 Extracorporeal Shockwave Therapy

9.6 Market Analysis

9.7 Competitive Analysis

9.7.1 Arthroscopic Surgery

9.7.2 Bone Growth Stimulation

9.7.3 Endoscopic Spinal Surgery

9.7.4 Extracorporeal Shockwave Therapy

10. UROLOGY APPLICATIONS OF DIRECTED ENERGY-BASED THERAPY

10.1 Benign Prostatic Hyperplasia

10.1.1 Surgical Treatment

10.1.1.1 Transurethral Resection of the Prostate

10.1.1.2 Transurethral Incision of the Prostate

10.1.1.3 Transurethral Vaporization of the Prostate

10.1.2 Directed Energy-Based Techniques

10.1.2.1 Transurethral Microwave Thermotherapy

10.1.2.1.1 Celsion

10.1.2.1.2 ProstaLund

10.1.2.1.3 TherMatrx/American Medical Systems

10.1.2.1.4 Urologix

10.1.2.2 Transurethral Needle Ablation

10.1.2.2.1 Medtronic

10.1.2.3 Laser-Based Therapy

10.1.2.3.1 Holmium Laser Enucleation of the Prostate

10.1.2.3.2 Interstitial Laser Coagulation

10.1.2.3.2.1 Johnson & Johnson

10.1.2.3.3 Photo-Selective Vaporization of the Prostate

10.1.2.3.3.1 Laserscope

10.1.2.3.4 Video Laser-Assisted Prostatectomy

10.1.2.4 Water-Induced Thermotherapy

10.1.2.5 High-Intensity Focused Ultrasound Therapy

10.1.2.6 Photodynamic Therapy

10.2 Urinary Stone Removal

10.2.1 Extracorporeal Shockwave Lithotripsy

10.2.1.1 Dornier MedTech

10.2.1.2 Siemens Medical Solutions/Siemens

10.2.2 Endoscopic Stone Removal

10.2.3 Percutaneous Nephrolithotomy

10.2.4 Intracorporeal Lithotripsy

10.2.4.1 Electrohydraulic Lithotripsy

10.2.4.2 Laser Lithotripsy

10.2.4.3 Pneumatic Lithotripsy

10.2.4.4 Ultrasonic Lithotripsy

10.3 Procedure Volumes

10.3.1 Benign Prostatic Hyperplasia

10.3.2 Urinary Stone Removal

10.3.2.1 Extracorporeal Shockwave Lithotripsy

10.3.2.2 Intracorporeal Lithotripsy

10.4 Market Analysis

10.4.1 Benign Prostatic Hyperplasia

10.4.2 Urinary Stone Removal

10.4.2.1 Extracorporeal Shockwave Lithotripsy Systems

10.4.2.2 Intracorporeal Lithotripsy Systems

10.5 Competitive Analysis

10.5.1 Benign Prostatic Hyperplasia

10.5.2 Urinary Stone Removal

10.5.2.1 Extracorporeal Shockwave Lithotripsy

10.5.2.2 Intracorporeal Lithotripsy

11. COMPANY PROFILES

11.1    Alcon, Inc./Nestlé SA

11.2    ArthroCare Corporation

11.3    Bausch & Lomb, Inc.

11.4    BIOLASE Technology, Inc.

11.5    Boston Scientific Corporation

11.6    Candela Corporation

11.7    CryoCath

11.8    Cytyc Surgical Products/Cytyc Corporation

11.9    EBI Medical, Inc./Biomet, Inc.

11.10  Endocare

11.11  Gyrus ENT LLC/Gyrus Group PLC

11.12  Johnson & Johnson

11.13  Laserscope, Inc.

11.14  Lumenis LTD

11.15  Medtronic, Inc.

11.16  RITA Medical Systems, Inc.

11.17  Smith & Nephew PLC

11.18  Spectranetics Corporation

11.19  Urologix, Inc.

11.20  VISX, Inc.

APPENDIX:  COMPANY LISTING

LIST OF EXHIBITS

Exhibit ES-1:    Directed Energy-Based Equipment, Procedure Volumes Forecast, by Therapeutic Area, 2003-2008

Exhibit ES-2:    Directed Energy-Based Equipment, Market Forecast, by Therapeutic Area, 2003-2008

Exhibit ES-3:    Directed Energy-Based Aesthetic Therapy, Market and Procedure Volumes Forecasts, 2003-2008

Exhibit ES-4:    Directed Energy-Based Cardiovascular Disease Therapy Products, Market Forecast, 2003-2008

Exhibit ES-5:    Dental Lasers, Market and Procedure Volumes Forecast, 2003-2008

Exhibit ES-6:    Directed Energy-Based Global Endometrial Ablation and Transcatheter Sterilization, Market Forecast, 2003-2008

Exhibit ES-7:    Directed Energy-Based Devices for Head and Neck Surgery, Market Forecast, 2003-2008

Exhibit ES-8:    Directed Energy-Based Oncologic Therapy Systems, Market and Procedure Volumes Forecast, 2003-2008

Exhibit ES-9:    Directed Energy-Based Ophthalmic Surgery Products, Market Forecast, by Type, 2003-2008

Exhibit ES-10:   Directed Energy-Based Orthopedic Therapy Systems, Market Forecast, 2003-2008

Exhibit ES-11:   Directed Energy-Based Benign Prostatic Hyperplasia Therapy Products, Market Forecast, 2003-2008

Exhibit ES-12:   Directed Energy-Based Urinary Stone Removal Systems, Market Forecast, 2003-2008

Exhibit 1-1:      2005, Selected High-Intensity Focused Ultrasound Devices

Exhibit 1-2:      Laser Devices, by Type and Application

Exhibit 1-3:      Laser Devices, by Type and Target, Based on Absorption Characteristics

Exhibit 2-1:      Average Electrolysis Treatment Times

Exhibit 2-2:      Advantages and Disadvantages of Laser- and Other Light-Based Hair Reduction Systems

Exhibit 2-3:      2005, Selected Laser- and Other Light-Based Hair Reduction Systems

Exhibit 2-4:      Electrolysis and Laser- and Light-Based Hair Reduction, Procedure Volumes Forecast, 2003-2008

Exhibit 2-5:      Advantages and Disadvantages of Selected Directed Energy-Based Devices for Nonablative Wrinkle Reduction and Skin Rejuvenation

Exhibit 2-6:      2005, Selected Laser and Other Light-Based Aesthetic Skin Treatment Systems

Exhibit 2-7:      Aesthetic Skin and Vascular Lesion Therapy, Procedure Volumes Forecast, 2003-2008

Exhibit 2-8:      Directed Energy-Based Aesthetic Therapy, Market and Procedure Volume Forecasts, 2003-2008

Exhibit 2-9:      2004, Directed Energy-Based Aesthetic Devices Market, Share by Supplier

Exhibit 3-1:      Directed Energy-Based Cardiovascular Disease Therapy Products, Market Forecast, 2003-2008

Exhibit 3-2:      2005, Selected Transcatheter Cardiac Arrhythmia Ablation Catheters

Exhibit 3-3:      Transcatheter Cardiac Arrhythmia Ablation Catheters, Market Forecast, 2003-2008

Exhibit 3-4:      Conventional Cardiac Arrhythmia Ablation Catheters, Market Forecast, 2003-2008

Exhibit 3-5:      Advanced Cardiac Arrhythmia Ablation Catheters, Market Forecast, 2003-2008

Exhibit 3-6:      2004, Conventional Cardiac Arrhythmia Ablation Catheters Market, Share by Supplier

Exhibit 3-7:      2004, Advanced Cardiac Arrhythmia Ablation Catheters Market, Share by Supplier

Exhibit 3-8:      2005, Selected Surgical Cardiac Arrhythmia Ablation Systems

Exhibit 3-9:      Surgical Cardiac Arrhythmia Ablation Probes, Market Forecast, 2003-2008

Exhibit 3-10:     2004, Surgical Cardiac Arrhythmia Ablation Probes Market, Share by Supplier

Exhibit 3-11:     Laser-Assisted Lead Extraction Systems, Market Forecast, 2003-2008

Exhibit 3-12:     Laser Angioplasty Devices, Market Forecast, 2003-2008

Exhibit 3-13:     Directed Energy-Based Products for Restenosis Management, Market Forecast, 2003-2008

Exhibit 3-14:     Transmyocardial Revascularization Products, Market Forecast, 2003-2008

Exhibit 3-15:     2004, Transmyocardial Revascularization Products Market, Share by Supplier

Exhibit 4-1:      2005, Selected Dental Laser Procedures

Exhibit 4-2:      2005, Selected Dental Lasers

Exhibit 4-3:      Dental Lasers, Procedure Volumes Forecast, 2003-2008

Exhibit 4-4:      Dental Lasers, Market and Procedure Volume Forecast, 2003-2008

Exhibit 4-5:      2004, Dental Lasers Market, Share by Supplier

Exhibit 5-1:      2005, Selected Current and Emerging Directed Energy-Based Global Endometrial Ablation Products

Exhibit 5-2:      Directed Energy-Based Menorrhagia Treatment, Procedure Volumes Forecast, 2003-2008

Exhibit 5-3:      Directed Energy-Based Global Endometrial Ablation and Transcatheter Sterilization, Market Forecast, 2003-2008

Exhibit 5-4:      2004, Directed Energy-Based Global Endometrial Ablation and Transcatheter Sterilization Market, Share by Supplier

Exhibit 6-1:      2005, Selected Directed Energy-Based Head and Neck Applications

Exhibit 6-2:      2005, Selected Directed Energy-Based Systems for Head and Neck Applications

Exhibit 6-3:      Directed Energy-Based Head and Neck Interventions, Procedure Volumes Forecast, 2003-2008

Exhibit 6-4:      Directed Energy-Based Devices for Head and Neck Surgery, Market Forecast, 2003-2008

Exhibit 6-5:      2004, Directed Energy-Based Devices Market for Head and Neck Surgery, Share by Supplier

Exhibit 7-1:      2005, Selected Directed Energy-Based Oncologic Therapy Systems

Exhibit 7-2:      Directed Energy-Based Oncologic Therapy Systems, Market and Procedure Volumes Forecast, 2003-2008

Exhibit 7-3:      2004, Cryoablation Oncologic Therapy Systems Market, Share by Supplier

Exhibit 7-4:      2004, Photodynamic Oncologic Therapy Systems Market, Share by Supplier

Exhibit 7-5:      2004, Radiofrequency Ablation Oncologic Therapy Systems Market, Share by Supplier

Exhibit 8-1:      2005, Selected Directed Energy-Based Systems for Vitreoretinal/Ocular Surgery

Exhibit 8-2:      2005, Selected Refractive Laser Surgery Systems

Exhibit 8-3:      Directed Energy-Based Vitreoretinal/Ocular Surgery, Procedure Volumes Forecast, 2003-2008

Exhibit 8-4:      Refractive Laser Surgery, Procedure Volumes Forecast, by Type, 2003-2008

Exhibit 8-5: &nb