EXECUTIVE SUMMARY

i.       Overview of Thermal Ablation

ii.       European Market for Thermal Ablation Devices

iii.      Methodology

 

Exhibit ES-1:    Thermal Effects on Tissue

Exhibit ES-2:    European Thermal Ablation Devices for Medically Necessary Care, Combined Market Forecast, 2011-2016

Exhibit ES-3:    European Thermal Ablation Devices for Medically Necessary Care, Market Forecast, by Treatment Segment, 2011-2016

 

1. SELECTED EUROPEAN HEALTHCARE MARKETS

1.1 The European Union

1.1.1 A Common Currency

1.1.1.1 The Sovereign Debt Crisis

1.1.2 Late Payments Directive

1.1.3 Regulatory Policies

1.1.4 Reimbursement

1.1.5 Healthcare Spending

1.2 Selected European National Healthcare Profiles

1.2.1 France

1.2.1.1 Healthcare Organization and Reform

1.2.1.2 Hospital Services

1.2.1.3 Medical Services/Supplies Reimbursement

1.2.2 Germany

1.2.2.1 Healthcare Organization and Reform

1.2.2.2 Hospital Services

1.2.2.3 Medical Services/Supplies Reimbursement

1.2.3 Italy

1.2.3.1 Healthcare Organization and Reform

1.2.3.2 Hospital Services

1.2.3.3 Medical Services/Supplies Reimbursement

1.2.4 Spain

1.2.4.1 Healthcare Organization and Reform

1.2.4.2 Hospital Services

1.2.4.3 Medical Services/Supplies Reimbursement

1.2.5 United Kingdom

1.2.5.1 Healthcare Organization and Reform

1.2.5.2 Hospital Services

1.2.5.3 Medical Services/Supplies Reimbursement

 

Exhibit 1-1:      European Union, Medical Device Risk Classification System

Exhibit 1-2:      European Union Population Statistics Comparison for the Years 2000, 2010, and 2020

Exhibit 1-3:      France, Selected National Healthcare Statistics

Exhibit 1-4:      Germany, Selected National Healthcare Statistics

Exhibit 1-5:      Italy, Selected National Healthcare Statistics

Exhibit 1-6:      Spain, Selected National Healthcare Statistics

Exhibit 1-7:      United Kingdom, Selected National Healthcare Statistics

 

2. THERMAL ABLATION DEVICES OVERVIEW

2.1 Applications for Thermal Ablation

2.1.1 Aesthetics—Skin Rejuvenation and Tightening

2.1.1.1 Alma Lasers

2.1.1.2 Cutera

2.1.1.3 Cynosure

2.1.1.4 Palomar Medical Technologies

2.1.1.5 Solta Medical

2.1.1.6 Syneron Medical

2.1.2 Aesthetics—Body Sculpting, Fat Reduction, and the Reduction in the Appearance of Cellulite

2.1.2.1 Cutera

2.1.2.2 Cynosure

2.1.2.3 Osyris Medical/LSO Medical

2.1.2.4 Solta Medical

2.1.2.5 Syneron Medical

2.1.2.6 Zeltiq Aesthetics

2.1.3 Benign Prostatic Hyperplasia

2.1.3.1 Transurethral Microwave Thermotherapy

2.1.3.1.1 American Medical Systems/Endo Health Solutions

2.1.3.1.2 Boston Scientific

2.1.3.1.3 ProstaLund Operations

2.1.3.1.4 Urologix

2.1.3.2 Transurethral Needle Ablation

2.1.3.3 Laser- and Other Energy-Based Therapies

2.1.3.3.1 Holmium Laser Ablation/Enucleation of the Prostate

2.1.3.3.1.1 Lumenis

2.1.3.3.2 Photoselective Vaporization of the Prostate

2.1.3.3.2.1 American Medical Systems/Endo Health Solutions

2.1.4 Cancer/Tumor Ablation

2.1.4.1 Radiofrequency Ablation

2.1.4.1.1 AngioDynamics

2.1.4.1.2 Boston Scientific

2.1.4.1.3 Celsion

2.1.4.1.4 Covidien

2.1.4.1.5 Thermedical

2.1.4.2 Other Ablation Methods

2.1.4.2.1 Cryoablation

2.1.4.2.1.1 Sanarus Technologies

2.1.4.2.2 Microwave Ablation

2.1.4.2.2.1 Covidien

2.1.4.2.2.2 Microsulis Medical and AngioDynamics

2.1.4.2.3 High-Intensity Focused Ultrasound

2.1.4.2.3.1 EDAP TMS

2.1.4.2.3.2 InSightec/ Elbit Imaging

2.1.5 Menorrhagia/Endometrial Ablation

2.1.5.1 Boston Scientific

2.1.5.2 CooperSurgical/The Cooper Companies

2.1.5.3 Ethicon/Johnson & Johnson

2.1.5.4 Hologic

2.1.6 Spinal Decompression and Denervation

2.1.6.1 ArthroCare

2.1.6.2 Relievant Medsystems

2.1.6.3 Smith & Nephew

2.1.7 Stress Urinary Incontinence

2.1.7.1 Novasys Medical

2.1.8 Varicose Vein Ablation

2.1.8.1 AngioDynamics

2.1.8.2 CermaVEIN

2.1.8.3 Covidien

2.1.9 Uterine Fibroids

2.1.9.1          InSightec/Elbit Imaging

2.1.9.2 Philips Healthcare/Royal Philips Electronics

 

Exhibit 2-1:      Thermal Effects on Tissue

Exhibit 2-2:      The Accent Radiofrequency Platform

Exhibit 2-3:      The Pixel CO2 Fractional Laser System and Technology

Exhibit 2-4:      The Thermage CPT System

Exhibit 2-5:      Sublative and Sublime Skin Rejuvenation Technologies

Exhibit 2-6:      The TruSculpt Body Sculpting System

Exhibit 2-7:      The Cellulaze Cellulite Laser Workstation

Exhibit 2-8:      The Smartlipo LaserBodySculpting Workstations

Exhibit 2-9:      The LipoControl GPS Laser Assisted Lipolysis System

Exhibit 2-10:    A Step-by-Step LipoSonix Procedure

Exhibit 2-11:    The VelaShape II System

Exhibit 2-12:    The UltraShape Contour I Body Sculpting System

Exhibit 2-13:    The CoolSculpting System and Step-by-Step Process

Exhibit 2-14:    Advantages and Disadvantages of Minimally Invasive Therapy for Benign Prostatic Hyperplasia

Exhibit 2-15:    The CoreTherm System

Exhibit 2-16:    Five-Year Clinical Comparison of Symptomatic Reduction in Benign Prostatic Hyperplasia Using the CoreTherm System and Competitive Treatments

Exhibit 2-17:    The CoolWave and Targis Systems

Exhibit 2-18:    The Cooled ThermCath Advance Catheter

Exhibit 2-19:    Cooled ThermoTherapy, Selected Five-Year Clinical Trial Results

Exhibit 2-20:    Comparison of Cooled ThermoTherapy with Drug Therapy, Selected Clinical Results

Exhibit 2-21:    The Prostiva Radiofrequency Therapy System

Exhibit 2-22:    Holmium Laser Ablation of the Prostate Using the VersaPulse PowerSuite Laser System

Exhibit 2-23:    Selected Advantages of Holmium Laser Ablation Using the VersaPulse PowerSuite Compared with Photoselective Vaporization Using the GreenLight PV

Exhibit 2-24:    The GreenLight High Performance System

Exhibit 2-25:    The GreenLight Xcelerated Performance System

Exhibit 2-26:    The MoXy Liquid Cooled Fiber

Exhibit 2-27:    The Model 1500X Electrosurgical Generator, and StarBurst Xli-Enhanced and Semi-Flex Electrodes

Exhibit 2-28:    The StarBurst SDE and MRI Electrodes

Exhibit 2-29:    The NanoKnife Low Energy Direct Current System and Electrode Probes

Exhibit 2-30:    The RF 3000 Generator and LeVeen Needle Electrode

Exhibit 2-31:    The Cool-tip RF Ablation System

Exhibit 2-32:    The Cool-tip RF Ablation System E Series

Exhibit 2-33:    The HALOFLEX System

Exhibit 2-34:    The SERF Ablation System

Exhibit 2-35:    The Visica 2 Treatment System and Step-by-Step Cryoablation Process

Exhibit 2-36:    The Evident MWA System

Exhibit 2-37:    The Acculis MTA System and Three-Step Procedure

Exhibit 2-38:    The Ablatherm Robotic HIFU System

Exhibit 2-39:    The ExAblate System

Exhibit 2-40:    Breast Cancer Treatment Using the ExAblate System

Exhibit 2-41:    The Three-Step Endometrial Ablation Process Using the Genesys Hydro ThermAblator System

Exhibit 2-42:    The Her Option Cryoablation System

Exhibit 2-43:    The Gynecare ThermaChoice III Uterine Balloon Therapy System and a Comparison of Selected Outcome Data with Competitive Thermal Ablation Systems

Exhibit 2-44:    The NovaSure System and Step-by-Step Endometrial Ablation Process

Exhibit 2-45:    Selected Features of the Next-Generation NovaSure System

Exhibit 2-46:    Nucleoplasty Using Coblation Technology

Exhibit 2-47:    Intradiscal Electrothermal Therapy and Targeted Disc Decompression

Exhibit 2-48:    Renessa Treatment for Stress Urinary Incontinence

Exhibit 2-49:    The VenaCure EVLT System

Exhibit 2-50:    The SVS System for the Treatment of Varicose Veins

Exhibit 2-51:    The Venefit Targeted Endovenous Therapy System

Exhibit 2-52:    Endovenous Ablation Using the Venefit System

Exhibit 2-53:    Uterine Fibroid Treatment Using the ExAblate System

Exhibit 2-54:    Sonalleve Therapy

 

3. EUROPEAN THERMAL ABLATION DEVICES MARKET

3.1 Procedure Volumes

3.2 Market Forecast

3.3 Competitive Analysis

3.3.1 Benign Prostatic Hyperplasia Ablation

3.3.2 Cancer/Tumor Ablation

3.3.3 Endometrial Ablation

3.3.4 Endovenous Ablation

3.4 Other Thermal Ablation Markets

3.4.1 Aesthetics

3.4.1.1 Body Sculpting/Fat Reduction

3.4.2 Spinal Disc Decompression and Denervation

 

Exhibit 3-1:      Europe, Thermal Ablation, Procedure Volumes Forecast, by Type, 2011-2016

Exhibit 3-2:      European Thermal Ablation Devices for Medically Necessary Care, Combined Market Forecast, 2011-2016

Exhibit 3-3:      European Thermal Ablation Devices for Medically Necessary Care, Market Forecast, by Treatment Segment, 2011-2016

Exhibit 3-4:      2011, European Thermal Ablation Devices Market for Medically Necessary Care, Share of Sales, by Segment

Exhibit 3-5:      2016, European Thermal Ablation Devices Market for Medically Necessary Care, Share of Sales, by Segment

Exhibit 3-6:      2011, Benign Prostatic Hyperplasia Laser Ablation Products Market, Share by Supplier

Exhibit 3-7:      2011, Benign Prostatic Hyperplasia Microwave and Radiofrequency Ablation Products Market, Share by Supplier

Exhibit 3-8:      2011, Tumor Ablation Products Market, Share by Supplier

Exhibit 3-9:      2011, Endometrial Ablation Products Market, Share by Supplier

Exhibit 3-10:    2011, Endovenous Ablation Products Market, Share by Supplier

Exhibit 3-11:    Leading Nonsurgical Aesthetic Device Companies,Global Revenues, 2010-2011

Exhibit 3-12:    2011, Global Nonsurgical Aesthetic Devices Market, Share by Supplier

Exhibit 3-13:    2012, Selected Nonsurgical Body Sculpting/Fat Reduction Systems

 

4. COMPANY PROFILES

4.1       AngioDynamics, Inc.

4.2       Boston Scientific Corporation

4.3       Covidien PLC

4.4       Endo Health Solutions, Inc.

4.5       Hologic, Inc.

4.6       InSightec LTD/Elbit Imaging LTD

4.7       Johnson & Johnson

4.8       Microsulis Medical LTD

4.9       Solta Medical, Inc.

4.10     Syneron Medical LTD

4.11     Zeltiq Aesthetics, Inc.

 

APPENDIX: COMPANY LISTING