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             Interventional Cardiologists' Adoption of 
Drug-Eluting Stents (DES) and Emerging Technologies
                                          #PS206

  • How do interventional cardiologists rate the promise of specific drug-eluting stents that 
    are currently in development?  And what issues do they think still need to be resolved 
    with drug-eluting stents?
  • Which indications for stent usage/application do they think will see the MOST growth over 
    the next two to three years?  (e.g., left main disease, multi-vessel disease, carotid disease, 
    other peripheral vessels, etc.).  
  • How do interventional cardiologists rate the effectiveness of drug-eluting stents, cutting 
    balloon angioplasty, coated stents, brachytherapy, drug therapy and other treatments for 
    preventing and treating restenosis?
  • Do they think their use of these treatments will increase, stay the same or decrease over 
    the next 2 to 3 years?
  •  How do interventional cardiologists rate the promise of new technologies and drugs for 
    restenosis that are in early stage development, including photoangioplasty, sonotherapy, 
    cryoplasty, hyperthermia, gene therapy/anti-sense drugs, halofuginone drug-eluting stent, 
    liposomal prostaglandin E1, polymer-based drug delivery and vascular endothelial growth 
    factors?

Medtech Insight went to the Transcatheter Cardiovascular Therapeutics (TCT) Conference 
to find out the answers to these and other provocative questions.  This Pr3 Physician Survey 
provides the need-to-know answers to various questions on drug-eluting stents and other 
emerging technologies and provides insight into interventional cardiologists’ practices, 
preferences and projections (Pr3).


Research Methods
Over 100 physicians participated in the survey, which was a self-administered, written survey 
conducted at the Transcatheter Cardiovascular Therapeutics (TCT) Conference in September 
2002
Physicians attending the conference were asked more than 80 questions (listed below).

SURVEY QUESTIONS
   (N=sample size)

Demographics

1.                  In which region of the country do you practice?                                   N=98

2.                  How many years have you been practicing interventional                      N=105
cardiology?

3.                  What type of practice are you in?                                                    N=105

4.                  What is your practice ownership?                                                     N=105

 

General Practices

5.                  How many interventional coronary procedures in TOTAL does your         N=102
institution perform per year?                                                                 

6.                  How many interventional coronary procedures in TOTAL do you             N=103
personally perform per year?                                                                                

Of the total coronary stent procedures that you perform annually, 
what percent are…

7.                  Primary stent procedures?                                                      N=99

8.                  SVG graft stents?                                                                 N=97

9.                  Single vessel stent procedures?                                               N=98

10.              Re-do stent procedures?                                                        N=96

11.              Multi-vessel stent procedures                                                  N=97

12.              Left main coronary artery disease?                                           N=89

13.              Is Fast CT available in your institution?                                               N=95

14.              Is IVUS available in your institution?                                                   N=102

15.              Is MRA available in your institution?                                                    N=96

 

Current Stent Practices and Preferences

16.              Top 10 stents used by interventional cardiologists in 2002                     N=104
(Manufacturer and product).

17.              Top 10 stents used by interventional cardiologists as a percent of the    N=104
total population, 2002.

18.              Have you been involved in any stent clinical trials in the last 2 to 3        N=105
 years?                                                                                                

19.              Which stent clinical trials were you involved in over the last 2 to 3         N=38 mentions
years? (Open-ended question)

20.              Have you been involved in any drug-eluting stent clinical trials in           N=105 
 the last 2 to 3 years?

21.              Which drug-eluting stent clinical trials were you involved in over            N=24 mentions
the last 2 to 3 years? (Open-ended question)                                          

22.              Which of the following vessels/indications will see the MOST growth in    N=104
stent usage/application over the next 2 to 3 years?
                                                                                                                                          

Brachytherapy and Restenosis

23.              Have you been involved in any intracoronary brachytherapy clinical        N=105
trials in the last 2 to 3 years?

24.              Which intracoronary brachytherapy clinical trials were you involved        N=20 mentions
in over the last 2 to 3 years?  (Open-ended question)                               

25.              How effective is stent-delivered radiation in preventing/treating            N=81 restenosis?                                                                                 

26.              How effective is catheter-delivered radiation in preventing/treating       N=96 restenosis?                                                                                

27.              Over the next 2 to 3 years, do you see your use of stent-delivered       N=80
brachytherapy for treating restenosis increasing, staying the same or 
decreasing?

28.              Over the next 2 to 3 years, do you see your use of catheter-delivered  N=92
brachytherapy for treating restenosis increasing, staying the same or 
decreasing?

 

Restenosis Alternatives

29.              How effective is angioplasty WITH stenting in preventing/treating         N=102 restenosis?                                                                                 

30.              How effective is angioplasty WITHOUT stenting in preventing/treating   N=101
restenosis?

31.              How effective is cutting balloon angioplasty in preventing/treating        N=100 restenosis?                                                                                

32.              How effective are atherectomy devices in preventing/treating             N=101 restenosis?                                                                                

33.              Over the next 2 to 3 years, do you see your use of atherectomy         N=98
devices for treating restenosis increasing, staying the same or 
decreasing?

34.              Over the next 2 to 3 years, do you see your use of angioplasty          N=102 
WITH stenting for treating restenosis increasing, staying the same 
or decreasing?                                                                                   

35.              Over the next 2 to 3 years, do you see your use of angioplasty          N=101
WITHOUT stenting for treating restenosis increasing, staying the 
same or decreasing?   

36.              Over the next 2 to 3 years, do you see your use of cutting balloon     N=101
angioplasty for treating restenosis increasing, staying the same 
or decreasing?

 

Stents and Restenosis

37.              How effective are coated stents in preventing/treating restenosis?          N=91

38.              How effective are drug-eluting stents in preventing/treating                   N=97
restenosis?

39.              How effective are biodegradable stents in preventing/treating                 N=62
restenosis?

40.              How effective is drug therapy in preventing/treating restenosis?              N=99

41.              A comparison of mean effectiveness ratings for treatments in 
preventing/treating restenosis (includes drug-eluting stents, 
catheter-delivered radiation, angioplasty with stenting, cutting balloon 
angioplasty, coated stents, biodegradable stents, stent-delivered 
radiation, atherectomy devices, drug therapy, and angioplasty without
stenting).

42.              Over the next 2 to 3 years, do you see your use of coated stents           N=94
(e.g, heparin, phosphorylcholine, gold) for treating restenosis increasing, 
staying the same, or decreasing?

43.              Over the next 2 to 3 years, do you see your use of drug-eluting stents    N=96
for treating restenosis increasing, staying the same, or decreasing?

44.              Over the next 2 to 3 years, do you see your use of biodegradable           N=64
stents for treating restenosis increasing, staying the same, or 
decreasing?

45.              Over the next 2 to 3 years, do you see your use of drug therapy            N=101
(NSAIDs, anti-platlet agents, etc.) for treating restenosis increasing, 
staying the same, or decreasing?

When performing coronary stenting procedures, what percent of the time do 
you use the following thrombolytics?

46.              Cor/Integrilin                                                                        N=93

47.              Lilly/Reopro                                                                          N=98

48.              Merck/Aggrastat                                                                   N=50

49.              Other GP IIb-IIIa inhibitors                                                      N=11

50.              What is the MOST important characteristic when deciding to choose a     N=104
coronary stent?

51.              What issues, if any do you believe still need to be resolved with             N=110 mentions
drug-eluting stents?  (Open-ended question)                                           

 

Physician Stent Preferences: Guidant

52.              Do you currently use GDT Multilink Penta stent?                                    N=104

53.              Do you currently use GDT Multilink Tetra stent?                                    N=104

54.              Do you currently use GDT Multilink Pixel stent?                                     N=104

55.              Do you currently use GDT Multilink Tristar stent?                                  N=104

56.              Do you currently use GDT Multilink Ultra stent?                                     N=104

57.              Based on your personal experience, word of mouth and research to           N=80
date, what is your impression regarding the promise of the Cook
Paclitaxel Logic stent to reduce restenosis?

 

Physician Stent Preferences: Cordis J&J

58.              Do you currently use Cordis/JNJ BX Velocity stent?                              N=104

59.              Do you currently use Cordis/JNJ BX Velocity Hepacoat stent?                N=104

60.              Do you currently use Cordis/JNJ Crossflex LC stent?                             N=104

61.              Based on your personal experience, word of mouth and research to        N=104
date, what is your impression regarding the promise of the JNJ/Cordis 
Sirolimus (Rapamycin)/BX Velocity stent to reduce restenosis?                                 

 

Physician Stent Preferences: Medtronic AVE

62.              Do you currently use Medtronic S7 stent?                                         N=104

63.              Do you currently use Medtronic S670 stent?                                      N=104

64.              Do you currently use Medtronic S660 stent?                                      N=104

65.              Do you currently use Medtronic S540 stent?                                      N=104

66.              Based on your personal experience, word of mouth and research to       N=46
date, what is your impression regarding the promise of the Medtronic 
Nitric Oxide stent to reduce restenosis?

Physician Stent Preferences: Boston Scientific

67.              Do you currently use BSX Niroyal Elite stent?                                      N=104

68.              Do you currently use  BSX Nir Elite stent?                                          N=104

69.              Do you currently use BSX Niroyal Elite Stainless stent?                         N=104

70.              Do you currently use BSX Niroyal Advance stent?                                N=104

71.              Based on your personal experience, word of mouth and research to        N=98
date, what is your impression regarding the promise of the BSX 
Paclitaxel/NIR stent to reduce restenosis?

 

Physician Stent Preferences: Abbott Vascular

72.              Do you currently use Abbott/Biocompatibles BiodivYsio-AS stent?          N=104

 

Emerging or Alternative Restenosis Technologies

73.              Do you currently use other stents not mentioned?                               N=104

74.              Based on your personal experience, word of mouth and research to        N=32
date, what is your impression regarding the promise of the STS 
Biopolymers Medi-coat stent to reduce restenosis?

75.              Based on what you have heard or read about photoangioplasty, what     N=101
is your initial impression regarding its promise to reduce restenosis?

76.              Based on what you have heard or read about sonotherapy what is         N=103
your initial impression regarding its promise to reduce restenosis?

77.              Based on what you have heard or read about cryoplasty what is your     N=101
initial impression regarding its promise to reduce restenosis?

78.              In your opinion, what is the likelihood of success for cryotherapy for       N=100
the treatment of restenosis?

79.              Based on what you have heard or read about hyperthermia, what is        N=99 
your initial impression regarding its promise to reduce restenosis?                               

80.              Based on what you have heard or read about gene therapy/anti-sense    N=103
drugs, what is your initial impression regarding its promise to reduce 
restenosis?      

81.              Based on what you have heard or read about halofuginone drug-eluting   N=101
stent, what is your initial impression regarding its promise to reduce 
restenosis?      

82.              Based on what you have heard or read about liposomal prostaglandin      N=99
E1, what is your initial impression regarding its promise to reduce 
restenosis?

83.              Based on what you have heard or read about polymer-based drug          N=103
delivery, what is your initial impression regarding its promise to reduce 
restenosis?      

84.              Based on your personal experience, word of mouth and research to        N=38
date, what is your impression regarding the promise of the Igaki-Tamai
biodegradable stent to reduce restenosis?

85.              Based on what you have heard or read about vascular endothelial          N=104
growth factors (VEGF), what is your initial impression regarding the 
promise to reduce restenosis?

86.              In your opinion, what is the likelihood of success for intravascular          N=100
ultrasound for the treatment of restenosis?

87.              In your opinion, what is the likelihood of success for photoangioplasty    N=100
for the treatment of restenosis?

88.              A comparison of treatments in development regarding their promise to 
prevent/treat restenosis (includes polymer-based drug delivery, VEGF, 
gene therapy/anti-sense drugs, sonotherapy, liiposomal prostaglandin 
E1, halofuginone DES, cryoplasty, photoangioplasty, and hyperthermia).                                           


© 2002, Medtech Insight, LLC


Ordering Information

Physician Survey #

# of Questions Format Price

PS206, Interventional Cardiologists' Adoption of Drug-Eluting Stents (DES) and Emerging Technologies

88

PowerPoint/
CD-ROM

$3,900


To purchase the results of this survey or for further inquiries, please contact 
pr3@medtechinsight.com
or call our sales office at (949) 219-0150 or toll 
free in the U.S. at (888) 290-2225.


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